Asian Pacific journal of tropical medicine · 2012
Antioxidant activity in HIV and malaria co-infected subjects in Anambra State, southeastern Nigeria.
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Osuji Faustina Nkechi, Onyenekwe Charles Chinedum, Ifeanyichukwu Martins, Ahaneku Joseph Ebere, Ezeani Micheal, Ezeugwunne Ifeoma Pricilla
Аннотация
OBJECTIVE: To determine the antioxidant status of HIV and malaria co-infected participants.
METHODS: Blood samples collected from the 193 randomly recruited participants were used for HIV screening, Plasmodium falciparum antigen screening, malaria parasite density count, CD4(+) T cell count, glutathione reductase, glutathione peroxidase and total antioxidant status measurement. Standard laboratory methods were used for the analysis.
RESULTS: The results showed that glutathione reductase, glutathione peroxidase, total antioxidant status and CD4(+) T cell count were significantly lowered in symptomatic HIV participants with and without malaria co-infection (P<0.01) in each case compared with control participants. Also, glutathione reductase, glutathione peroxidise, total antioxidant status and CD4(+) T cell count were significantly lowered in asymptomatic HIV participants with and without malaria co-infection (P<0.05) in each case, compared with control participants without malaria. Similarly, these antioxidants were significantly lowered in control participants with malaria infection (P<0.05) compared with control participants without malaria. The malaria parasite density in symptomatic HIV infected participants was negatively associated with glutathione reductase (r = -0.906, P<0.01), glutathione peroxidase (r = -0.719, P<0.01) and total antioxidant status (r = -0.824, P<0.01).
CONCLUSIONS: The antioxidant activity was affected in HIV infected participants with malaria co-infection. Malaria co-infection in HIV seems to exert additional burden on antioxidants. This calls for concern in malaria endemic areas with increasing prevalence of HIV infection.
METHODS: Blood samples collected from the 193 randomly recruited participants were used for HIV screening, Plasmodium falciparum antigen screening, malaria parasite density count, CD4(+) T cell count, glutathione reductase, glutathione peroxidase and total antioxidant status measurement. Standard laboratory methods were used for the analysis.
RESULTS: The results showed that glutathione reductase, glutathione peroxidase, total antioxidant status and CD4(+) T cell count were significantly lowered in symptomatic HIV participants with and without malaria co-infection (P<0.01) in each case compared with control participants. Also, glutathione reductase, glutathione peroxidise, total antioxidant status and CD4(+) T cell count were significantly lowered in asymptomatic HIV participants with and without malaria co-infection (P<0.05) in each case, compared with control participants without malaria. Similarly, these antioxidants were significantly lowered in control participants with malaria infection (P<0.05) compared with control participants without malaria. The malaria parasite density in symptomatic HIV infected participants was negatively associated with glutathione reductase (r = -0.906, P<0.01), glutathione peroxidase (r = -0.719, P<0.01) and total antioxidant status (r = -0.824, P<0.01).
CONCLUSIONS: The antioxidant activity was affected in HIV infected participants with malaria co-infection. Malaria co-infection in HIV seems to exert additional burden on antioxidants. This calls for concern in malaria endemic areas with increasing prevalence of HIV infection.