Journal of cosmetic dermatology · 2025
Ocular Surveillance During Off-Label Oral Isotretinoin for Photoaging: A Review of Risks and Monitoring Recommendations.
СтатьяОбзорНазвание и аннотация: Перевод пока не подготовлен
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Magacho-Vieira Fabiano Nadson, Dias Gilmasa Daniele Rios
Аннотация
BACKGROUND: Low-dose oral isotretinoin is increasingly used off-label for photoaging, with evidence of clinical and histologic skin improvement.
OBJECTIVE: To review ocular risks associated with isotretinoin in aesthetic use and propose monitoring recommendations.
METHODS: A narrative review of clinical studies, observational data, and mechanistic reports addressing isotretinoin-induced ocular effects was performed, integrating dermatologic and ophthalmologic perspectives.
RESULTS: Reported adverse effects include dry eye disease, meibomian gland dysfunction, and, rarely, retinal alterations. Risk may be cumulative in long-term or repeated cosmetic regimens.
CONCLUSION: A risk-adapted monitoring approach, emphasizing patient selection, informed consent, and interdisciplinary care, is recommended to balance cosmetic benefits with ocular safety.
OBJECTIVE: To review ocular risks associated with isotretinoin in aesthetic use and propose monitoring recommendations.
METHODS: A narrative review of clinical studies, observational data, and mechanistic reports addressing isotretinoin-induced ocular effects was performed, integrating dermatologic and ophthalmologic perspectives.
RESULTS: Reported adverse effects include dry eye disease, meibomian gland dysfunction, and, rarely, retinal alterations. Risk may be cumulative in long-term or repeated cosmetic regimens.
CONCLUSION: A risk-adapted monitoring approach, emphasizing patient selection, informed consent, and interdisciplinary care, is recommended to balance cosmetic benefits with ocular safety.