[The relationship between autoimmune thyroiditis and pregnancy outcomes of patients with PCOS following in vitro fertilization and embryo transfer IVF-ET].

Objective: To investigate the impact of autoimmune thyroiditis (AIT) on pregnancy outcomes in patients with polycystic ovary syndrome (PCOS) following the in vitro fertilization and embryo transfer (IVF-ET) by analyzing their pregnancy outcomes. Methods: The patients undergoing IVF-ET treatment diagnosed with PCOS in Peking University Third Hospital from May 2010 to December 2014 were investigated. According to the anti-thyroid antibodies (TPOAb or TGAb), patients were divided into AIT group and non-AIT group. The pregnancy outcomes of two groups were analysed for investigate the effect of AIT on pregnancy outcomes. Results: Four hundred and ninety patients with PCOS were enrolled, 119 (24.3%) of AIT group and 371 (75.7%) of non-AIT group. Patients with PCOS had a higher incidence (24.3%) of AIT. There was no correlation between AIT and the different pregnancy outcomes.TSH was negatively correlated with pregnancy as a risk factor. Hyperandrogenemia was negatively correlated with clinical pregnancy as a risk factor. Hyperprolactinemia was negatively correlated with delivery as a risk factor, while TSH was positively correlated with delivery. Conclusions: The incidence of AIT was higher in patients with PCOS. AIT was not the risk factor of adverse pregnancy outcomes for PCOS women undergoing IVF. The metabolic disorders (including hyperinsulinemia, hyperandrogenemia and hyperprolactinemia) were the risk factors of adverse pregnancy outcomes. Patients in AIT group had the high TSH level. They should be received more care and monitoring to make it conducive to delivery.