The Australasian journal of dermatology · 2025
Cutaneous Infiltration of Waldenstrom's Macroglobulinaemia-A Two-Case Series of a Diagnostically Challenging Presentation.
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Narula Monica, Mahar Patrick D, Tan Edwin Wee Hian, Singh Naveen, Lade Stephen, Prince Henry Miles, McCormack Christopher
Аннотация
BACKGROUND/OBJECTIVES: Cutaneous manifestations of Waldenstrom's macroglobulinaemia (WM), a rare B-cell lymphoproliferative disorder, present a diagnostic challenge. The intent of this article is to raise awareness to clinicians of a potentially overlooked condition, particularly in the context of patients with a monoclonal IgM paraproteinaemia, but also to describe the diagnostic complexity of the disease from a clinicopathological perspective.
METHODS: We describe the clinical presentation and histopathological findings of two patients with cutaneous involvement of WM.
RESULTS: Cutaneous presentations included erythematous and salmon pink plaques, which were either tender or non-tender. Histopathology analysis in both cases demonstrated direct lymphocytic infiltration by malignant lymphocytes of WM, with case 1 demonstrating aberrant CD10 expression.
CONCLUSION: The broad cutaneous signs of WM are sparsely described in the literature, and these can even precede formal diagnosis. Ongoing clinical suspicion is warranted from both a clinical and histopathological perspective where patients present with a monoclonal IgM paraproteinemia.
METHODS: We describe the clinical presentation and histopathological findings of two patients with cutaneous involvement of WM.
RESULTS: Cutaneous presentations included erythematous and salmon pink plaques, which were either tender or non-tender. Histopathology analysis in both cases demonstrated direct lymphocytic infiltration by malignant lymphocytes of WM, with case 1 demonstrating aberrant CD10 expression.
CONCLUSION: The broad cutaneous signs of WM are sparsely described in the literature, and these can even precede formal diagnosis. Ongoing clinical suspicion is warranted from both a clinical and histopathological perspective where patients present with a monoclonal IgM paraproteinemia.