Archives of oral biology · 2026
Immunohistochemical expression of SPARC and MMP-9 in odontogenic keratocysts and orthokeratinized odontogenic cysts.
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Qu Jiafei, Yuan Shasha, Zhang Xinna, Shang Jianwei, Wang Lixia, Gao Jing, Li Lu, Liang Fangfang, Zhao Chen, Shen Jing
Аннотация
OBJECTIVE: Odontogenic keratocysts (OKCs) are locally aggressive odontogenic cysts with high recurrence propensity, whereas orthokeratinized odontogenic cysts (OOCs) are indolent. Secreted protein acidic and rich in cysteine (SPARC) and matrix metalloproteinase 9 (MMP-9) have been implicated in tumor invasion. This study aimed to evaluate and compare the immunohistochemical expression of SPARC and MMP-9 in sporadic OKCs and OOCs, and to further explore the potential association between these two proteins in both types of cysts.
DESIGN: SPARC and MMP-9 expression were evaluated in 24 sporadic OKCs and 22 OOCs using immunohistochemistry.
RESULTS: In the epithelium of OKCs and OOCs, SPARC was absent. In the connective tissue, SPARC was predominantly detected in fibroblast cytoplasm, with significantly higher expression in OKCs than in OOCs (p = 0.006). MMP-9 was localized in both epithelium and connective tissue. Compared with OOCs, OKCs showed upregulated MMP-9 expression in the epithelium (p = 0.035), whereas no significant difference in MMP-9 expression was observed in the connective tissue between the two types of cysts (p = 0.678). A positive correlation was observed between SPARC and MMP-9 in the connective tissue of OKC. Furthermore, both SPARC and MMP-9 demonstrated a significant positive association with inflammatory infiltration in OKCs.
CONCLUSION: Increased SPARC expression in sporadic OKCs compared to OOCs suggests that SPARC may play a role in OKC aggressiveness. Differential expression of SPARC may aid in distinguishing between OKC and OOC. Moreover, the putative association between SPARC and MMP-9 in OKCs may contribute to their local invasiveness.
DESIGN: SPARC and MMP-9 expression were evaluated in 24 sporadic OKCs and 22 OOCs using immunohistochemistry.
RESULTS: In the epithelium of OKCs and OOCs, SPARC was absent. In the connective tissue, SPARC was predominantly detected in fibroblast cytoplasm, with significantly higher expression in OKCs than in OOCs (p = 0.006). MMP-9 was localized in both epithelium and connective tissue. Compared with OOCs, OKCs showed upregulated MMP-9 expression in the epithelium (p = 0.035), whereas no significant difference in MMP-9 expression was observed in the connective tissue between the two types of cysts (p = 0.678). A positive correlation was observed between SPARC and MMP-9 in the connective tissue of OKC. Furthermore, both SPARC and MMP-9 demonstrated a significant positive association with inflammatory infiltration in OKCs.
CONCLUSION: Increased SPARC expression in sporadic OKCs compared to OOCs suggests that SPARC may play a role in OKC aggressiveness. Differential expression of SPARC may aid in distinguishing between OKC and OOC. Moreover, the putative association between SPARC and MMP-9 in OKCs may contribute to their local invasiveness.