Hunan yi ke da xue xue bao = Hunan yike daxue xuebao = Bulletin of Hunan Medical University · 2002
[Therapeutic effect of the recombinant human granulocyto colony-stiimulating factor on radiation-induced agranulocytosis models of mice].
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Zhu Hong, Lai Fu-ying, Sun Li
Аннотация
OBJECTIVE: To observe the effect of the recombinant human granulocyto colony-stimulating factor (rhG-CSF) on radiation-induced neutropenia models of mice.
METHODS: rhG-CSF in 2 different doses (10 micrograms.kg-1.d-1 and 30 micrograms.kg-1.d-1) was injected respectively to radiation-induced neutropenia models of mice. The effect of rhG-CSF on the weight of the spleen, CFU-S, leukocyte counts, neutrophil counts, and CFU-GM of the marrow cell culture was observed.
RESULTS: Both 30 and 10 micrograms.kg-1.d-1 of rhG-CSF increased CFU-GM of the marrow cell culture and the peripheral leukocyte and neutrophil, showing a significant difference compared with the NS control group (P < 0.05).
CONCLUSION: rhG-CSF has a significant therapeutic effect on radiation-induced agranulocytosis models of mice.
METHODS: rhG-CSF in 2 different doses (10 micrograms.kg-1.d-1 and 30 micrograms.kg-1.d-1) was injected respectively to radiation-induced neutropenia models of mice. The effect of rhG-CSF on the weight of the spleen, CFU-S, leukocyte counts, neutrophil counts, and CFU-GM of the marrow cell culture was observed.
RESULTS: Both 30 and 10 micrograms.kg-1.d-1 of rhG-CSF increased CFU-GM of the marrow cell culture and the peripheral leukocyte and neutrophil, showing a significant difference compared with the NS control group (P < 0.05).
CONCLUSION: rhG-CSF has a significant therapeutic effect on radiation-induced agranulocytosis models of mice.