Медицинская библиотека · Hunan yi ke da xue xue bao = Hunan yike daxue xuebao = Bulletin of Hunan Medical University · 2002

[Therapeutic effect of the recombinant human granulocyto colony-stiimulating factor on radiation-induced agranulocytosis models of mice].

Zhu Hong, Lai Fu-ying, Sun Li

Аннотация на английскомСтатьяПеревод пока не подготовлен

Аннотация

OBJECTIVE

To observe the effect of the recombinant human granulocyto colony-stimulating factor (rhG-CSF) on radiation-induced neutropenia models of mice.

METHODS

rhG-CSF in 2 different doses (10 micrograms.kg-1.d-1 and 30 micrograms.kg-1.d-1) was injected respectively to radiation-induced neutropenia models of mice. The effect of rhG-CSF on the weight of the spleen, CFU-S, leukocyte counts, neutrophil counts, and CFU-GM of the marrow cell culture was observed.

RESULTS

Both 30 and 10 micrograms.kg-1.d-1 of rhG-CSF increased CFU-GM of the marrow cell culture and the peripheral leukocyte and neutrophil, showing a significant difference compared with the NS control group (P < 0.05).

CONCLUSION

rhG-CSF has a significant therapeutic effect on radiation-induced agranulocytosis models of mice.

Для цитирования: Zhu Hong, Lai Fu-ying, Sun Li. [Therapeutic effect of the recombinant human granulocyto colony-stiimulating factor on radiation-induced agranulocytosis models of mice].. Hunan yi ke da xue xue bao = Hunan yike daxue xuebao = Bulletin of Hunan Medical University. 2002.

Предметные рубрики MeSH

Agranulocytosis Animals Bone Marrow Cells Female Granulocyte Colony-Stimulating Factor Leukocyte Count Male Mice Mice, Inbred BALB C Radiation Injuries, Experimental Recombinant Proteins

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