International journal of dermatology · 2015
Epithelial antigenic specificities of circulating autoantibodies in mucosal lichen planus.
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Herrero-González Josep E, Parera Amer Elisabet, Segura Sonia, Mas Bosch Virgínia, Pujol Ramon Maria, Martínez Escala Maria E
Аннотация
BACKGROUND: Mucosal lichen planus (LP) is an inflammatory disease of the mucous membranes of unknown origin. The antigen-specific autoantibodies or T cells responsible for this disease have not yet been established.
OBJECTIVES: This study was designed to study the antigenic specificities of circulating antibodies in patients with mucosal LP and to review previous findings on this topic.
METHODS: We tested a series of consecutive cases of mucosal LP in our clinic by enzyme-linked immunosorbent assay using desmoglein 3 (Dsg3) and BP180 fusion proteins.
RESULTS: Three of 22 patients were positive for anti-NC16A antibodies. Interestingly, we found a middle-aged woman with severe disease with circulating anti-Dsg3 antibodies at high levels, typical of pemphigus vulgaris. Levels of these antibodies positively correlated with the severity of clinical manifestations. We failed to detect anti-desmoglein antibodies in any other patient in our series and in the literature review.
CONCLUSIONS: Some patients with mucosal LP may present with circulating anti-BP180 antibodies at low levels. We also report the first case with positive anti-Dsg3 antibodies. The pathogenic relevance of these autoantibodies remains unknown.
OBJECTIVES: This study was designed to study the antigenic specificities of circulating antibodies in patients with mucosal LP and to review previous findings on this topic.
METHODS: We tested a series of consecutive cases of mucosal LP in our clinic by enzyme-linked immunosorbent assay using desmoglein 3 (Dsg3) and BP180 fusion proteins.
RESULTS: Three of 22 patients were positive for anti-NC16A antibodies. Interestingly, we found a middle-aged woman with severe disease with circulating anti-Dsg3 antibodies at high levels, typical of pemphigus vulgaris. Levels of these antibodies positively correlated with the severity of clinical manifestations. We failed to detect anti-desmoglein antibodies in any other patient in our series and in the literature review.
CONCLUSIONS: Some patients with mucosal LP may present with circulating anti-BP180 antibodies at low levels. We also report the first case with positive anti-Dsg3 antibodies. The pathogenic relevance of these autoantibodies remains unknown.