American journal of clinical dermatology · 2012
Alterations in serum lipid profile patterns in oral lichen planus: a cross-sectional study.
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López-Jornet Pia, Camacho-Alonso Fabio, Rodríguez-Martínes M Angeles
Аннотация
BACKGROUND: Oral lichen planus (OLP) is a chronic inflammatory disorder. Recently, a case-control study found that lichen planus was associated with dyslipidemia in a large series of patients. However, no data were presented about lipid values in patients and controls.
OBJECTIVES: The aim of this study was to investigate the hypothetical association between OLP and dyslipidemia.
MATERIALS AND METHODS: The study included a total of 400 patients (200 with OLP and 200 controls with other oral diseases) and investigated the prevalence of dyslipidemia. The variables analyzed were age, sex, tobacco and alcohol consumption, clinical form of OLP and lipid profiles.
RESULTS: A 54% prevalence of dyslipidemia was found (58% among the OLP group and 50% in the control group). Statistically significant differences in high-density lipoprotein were found between OLP patients and the control group (p = 0.003). A logistic regression model for presence/absence of cardiovascular risk (Castelli's atherogenic index of ≥ 5.1 for men and ≥ 4.5 for women) found statistically significant differences for sex and tobacco consumption.
CONCLUSIONS: The study found a higher atherogenic index amongst OLP patients.
OBJECTIVES: The aim of this study was to investigate the hypothetical association between OLP and dyslipidemia.
MATERIALS AND METHODS: The study included a total of 400 patients (200 with OLP and 200 controls with other oral diseases) and investigated the prevalence of dyslipidemia. The variables analyzed were age, sex, tobacco and alcohol consumption, clinical form of OLP and lipid profiles.
RESULTS: A 54% prevalence of dyslipidemia was found (58% among the OLP group and 50% in the control group). Statistically significant differences in high-density lipoprotein were found between OLP patients and the control group (p = 0.003). A logistic regression model for presence/absence of cardiovascular risk (Castelli's atherogenic index of ≥ 5.1 for men and ≥ 4.5 for women) found statistically significant differences for sex and tobacco consumption.
CONCLUSIONS: The study found a higher atherogenic index amongst OLP patients.