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Войти в исследования The Medical Impact of Hepatitis D Virus Infection in Natives and Immigrants: The Italian Paradigm.
Обработка статьи · этапы, ошибки и управление
Ошибки и ограничения
История · было → стало
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Caviglia Gian Paolo, Dileo Eleonora, Olivero Antonella, Mengozzi Giulio, Ciancio Alessia, Loglio Alessandro, Viganò Mauro, Fagiuoli Stefano, Colombatto Piero, Coco Barbara, Brunetto Maurizia Rossana, Angrisani Debora, Galeota Lanza Alfonso, Magni Carlo, Rizzardini Giuliano, Messina Vincenzo, Milella Michele, Saracino Annalisa, Marinaro Letizia, Cariti Giuseppe, Cossiga Valentina, Morisco Filomena, Cretella Silvia, Verucchi Gabriella, Biliotti Elisa, D'Offizi Giampiero, Feasi Marcello, Pontali Emanuele, Coppola Carmine, Rapetti Rachele, Pirisi Mario, Izzi Antonio, Santantonio Teresa, Di Marco Vito, Marrone Aldo, Coppola Nicola, Rizzi Marco, Cattelan Anna Maria, Niro Grazia Anna, Toniutto Pierluigi, Ponziani Francesca Romana, Belli Luca Saverio, Federico Alessandro, Bertino Gaetano, Barone Michele, Puoti Massimo, Civolani Alberto, Distefano Marco, Surace Lorenzo Antonio, Cozzolongo Raffaele, Cela Ester Marina, Teti Elisabetta, Lampertico Pietro, Stroffolini Tommaso, Rizzetto Mario, HDV Describe Study Group
Аннотация
METHODS: We enrolled 515 hepatitis B surface antigen (HBsAg)-positive patients with detectable anti-HDV antibodies from 32 Italian centres between August 2022 and July 2024; all patients underwent centralised virologic assessment.
RESULTS: Overall, 432 out of 515 (83.9%) patients were HDV-RNA-positive (4.39, 1.30-5.82 Log IU/mL; 99.0% HDV genotype-1). HDV-RNA levels correlated with ALT (rs = 0575, 0.514-0.630) and hepatitis B core-related antigen (rs = 0.521, 0.455-0.581). Native Italians (n = 317; 61.6%) were older than migrants (n = 198; 38.4%) (median age: 60, 55-65 vs. 46, 39-54 years; p < 0.001) and were more frequently male (68.1% vs. 49.5%; p < 0.001), with a higher prevalence of liver cirrhosis (70.3% vs. 50.5%; p < 0.001) and hepatocellular carcinoma (14.8% vs. 0.5%; p < 0.001). Among Italians, 223 (70.3%) had liver cirrhosis, 46 (14.5%) had chronic hepatitis D (CHD) without cirrhosis and 48 (15.1%) exhibited inactive/minimal disease with low viremia (≤ 3 Log IU/mL). Among migrants, 100 (50.5%) had liver cirrhosis, 58 (29.3%) had CHD and 40 (20.2%) showed inactive/minimal disease with low viremia (≤ 3 Log IU/mL).
CONCLUSIONS: The current clinical landscape of chronic HDV infections in Italy is heterogeneous, changing the perspective of CHD as uniformly severe; although cirrhosis remains common, a substantial proportion of both native Italians and migrants present with milder forms of disease.