Ocular manifestations of sickle cell disease.

1. Sickle cell disease in the eye primarily affects the retina. Other ocular findings include conjunctival sickling sign, lid edema secondary to sickle crisis, iris atrophy, and iris neovascularization. 2. Treatment of proliferative sickle cell retinopathy depends on the stage of the disease. Feeder vessel photocoagulation has been shown to be effective in closing sea fans and reducing the incidence of visual loss in Stage III disease. 3. Education and awareness to the potential complications of proliferative retinopathy leads us to the awareness that prevention is the best treatment for sickle cell retinopathy.