Biochemical and biophysical research communications · 2021
Plakophilin3 loss leads to increased adenoma formation and rectal prolapse in APCmin mice.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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Raghavan Rahul, Koyande Navami, Beher Rohit, Chetlangia Neha, Ramadwar Mukda, Pawade Shital, Thorat Rahul, van Hengel Jolanda, Sklyarova Tetyana, van Roy Frans, Dalal Sorab N
Аннотация
Plakophilin3 (PKP3) loss leads to tumor progression and metastasis of colon cancer cells. The goal of this report was to determine if PKP3 loss led to increased disease progression in mice. We generated a colonocyte-specific knockout of PKP3 in APCmin mice, which led to increased adenoma formation, the formation of rectal prolapse, and a significant decrease in survival. The observed increase in rectal prolapse formation and decrease in survival correlated with an increase in the expression of Lipocalin2 (LCN2). Increased disease progression was observed even upon treatment with 5-fluorouracil (5FU). These results suggest that an increase in LCN2 expression might lead to therapy resistance and that LCN2 might serve as a potential therapeutic target in colorectal cancer.
Предметные рубрики MeSH
AdenomaAnimalsAntimetabolites, AntineoplasticColonColorectal NeoplasmsDisease ProgressionDrug Resistance, NeoplasmFemaleFluorouracilGene Expression Regulation, NeoplasticKeratin-8Lipocalin-2MaleMatrix Metalloproteinase 7MiceMice, Inbred C57BLMice, TransgenicPlakophilinsRectal ProlapseSignal TransductionSurvival Analysis