Prevalence of human parvovirus B19 in sickle cell disease and healthy controls.

The serological HPV status of 35 patients with SCA (Hb SS), randomly chosen from a sickle cell clinic in rural south-west Togo and of 13 household members with normal haemoglobin type (Hb AA) was assessed. No difference in HPV-IgG seropositivity rate was found. In 30 urban hospital patients from Abidjan, Ivory Coast, who were in acute painful sickle cell crisis HPV-IgG seropositivity rate increased with age. In only one (HIV positive) patient HPV-IgM antibodies were detected. It is concluded that HPV-infection exists in West Africa (1) and that there is no evidence for increased seroprevalence in SCA (2). HPV does not seem to trigger acute painful crises in SCA (3). The age-specific HPV seropositivity increase in urban patients may be due to differing transmission rates in urban and rural areas.