Orphanet journal of rare diseases · 2026
Clinical characteristics of tumor-induced osteomalacia lesions in the neurocranium and intracranial structures.
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Wu Yushuo, Li Xiang, Xu Zhiqin, Lv Wei, Wang Zhixiang, Ni Xiaolin, Pang Qianqian, Jiajue Ruizhi, Chi Yue, Liu Wei, Cui Lijia, Jiang Yan, Wang Ou, Li Mei, Xing Xiaoping, Ma Wenbin, Wang Yu, Yao Yong, Guo Yi, Gao Zhiqiang, Feng Guodong, Qi Fang, Gong Yiyi, Xia Weibo
Аннотация
BACKGROUND: Tumor-induced osteomalacia (TIO) is a rare paraneoplastic syndrome caused by excessive fibroblast growth factor 23 (FGF23) secretion. However, TIO lesions located in the neurocranium (NC) and intracranial (IC) structures remain poorly characterized.
OBJECTIVE: To characterize the clinical features of TIO lesions in NC and IC structures and to compare them with those located in the sinuses.
METHODS: This retrospective study included patients diagnosed with TIO who underwent tumor resection at Peking Union Medical College Hospital between January 2016 and December 2023. Patients with lesions in NC and IC structures were defined as the study group, while those with sinus lesions served as the control group. Clinical characteristics, biochemical parameters, and surgical outcomes were systematically analyzed and compared between groups.
RESULTS: TIO lesions in NC and IC structures were distributed across the skull base, temporal region, sellar region, frontal lobe, and occipital region. Compared with sinus lesions, patients with NC and IC lesions showed comparable clinical and biochemical profiles but exhibited significantly worse outcomes, including higher rates of non-remission and tumor recurrence. These findings suggest increased difficulty in complete tumor resection and disease control in this subgroup.
CONCLUSION: TIO lesions in NC and IC structures are associated with poorer surgical outcomes and higher recurrence rates despite similar baseline characteristics. These results highlight the need for improved localization strategies and tailored management approaches for this challenging subgroup.
OBJECTIVE: To characterize the clinical features of TIO lesions in NC and IC structures and to compare them with those located in the sinuses.
METHODS: This retrospective study included patients diagnosed with TIO who underwent tumor resection at Peking Union Medical College Hospital between January 2016 and December 2023. Patients with lesions in NC and IC structures were defined as the study group, while those with sinus lesions served as the control group. Clinical characteristics, biochemical parameters, and surgical outcomes were systematically analyzed and compared between groups.
RESULTS: TIO lesions in NC and IC structures were distributed across the skull base, temporal region, sellar region, frontal lobe, and occipital region. Compared with sinus lesions, patients with NC and IC lesions showed comparable clinical and biochemical profiles but exhibited significantly worse outcomes, including higher rates of non-remission and tumor recurrence. These findings suggest increased difficulty in complete tumor resection and disease control in this subgroup.
CONCLUSION: TIO lesions in NC and IC structures are associated with poorer surgical outcomes and higher recurrence rates despite similar baseline characteristics. These results highlight the need for improved localization strategies and tailored management approaches for this challenging subgroup.