Studies on acute and late stages of experimental central retinal artery occlusion in the Cynomolgus monkey. I. Intensity-amplitude relations of the D.C. recorded ERG with special reference to the c-wave.

The main positive component of the c-wave of the ERG is generated by the pigment epithelium-receptor complex, which is supplied from the choroidal circulation. Occlusion of the central retinal artery (OCRA) causes serious morphological damage only to the inner retina. An effect on the c-wave is therefore not primarily to be expected. In this study on five Cynomolgus monkeys with unilateral, laser-induced OCRA the c-wave was decreased, slightly in the early stage and markedly in the late stage. A hypothetical explanation of the reduced c-wave amplitude, involving changes in potassium ion concentration, is discussed. The conflicting results in other reports may be explained by uncontrolled influence of slow c-wave amplitude oscillations, by differences between acute and late stages, and by possible surgical damage to the choroidal circulation in some cases.