New enteric vaccines: application of new knowledge of receptors and recognition in enteric infections.

Advances in understanding of the "receptors and recognition" mechanisms of virulence factors of enteric pathogens have been important in the development of enteric vaccines. Sophisticated techniques of molecular biology have proved essential to this endeavour. This review summarizes progress in development of vaccines against disease due to Vibrio cholerae, Escherichia coli, Salmonella typhi, Shigella and rotavirus enteric infections. All of these vaccines are undergoing, or are about to undergo, field trials.