Journal of clinical medicine · 2025

Prevalence of MASLD and Fibrosis Risk in Turkish Adults with Cardiometabolic Risk Factors: A Nationwide Multicenter Study (DAHUDER MASLD Study).

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Kirik Ali, Sumbul Hilmi Erdem, Koca Nizameddin, Paşalı Kilit Türkan, Demiral Sezer Sibel, Binnetoglu Emine, Araç Eşref, Solmaz İhsan, Şen Hacer, Demirci İbrahim, Abaylı Bahri, Akan Hale, Akkuş Canan, Aksakal Berrin, Aktas Gulali, Alakuş Ömer Faruk, Atak Tel Burçin Meryem, Aydın Ahmet, Bahçebaşı Sami, Balıkçı Orhan, Saka Baraz Lale, Başgöz Bilgin Bahadır, Bayrak Muharrem, Bektaş Uysal Hilal, Beyazal Polat Hatice, Biçer İfakat İrem, Bozkuş Rıfat, Coşkun Fatih, Çağatay Cüneyt, Çağlar Feride, Çakmak Erkan, Cekiç Deniz, Değer Ülfet, Demir Ayse Kevser, Demir İsmail, Dizdar Oğuzhan Sıtkı, Dulkadiroğlu Erkan, Düzen Oflas Nur, Erişmiş Betül, Erol Ali, Ertınmaz Ayşegül, Eryılmaz Müzeyyen, Gemcioğlu Emin, Genç Ahmed Bilal, Gökgöz Melis, Gözel Nevzat, İleri Fatih, İşsever Kubilay, İzlimek Uğur Can, Kama Başcı Özge, Kamburoğlu Aynur, Kamış Fatih, Kayhan Sanem, Kırlı İsmail, Kimyon Yusuf, Kocaman Şeref Enes, Konur Kamil, Kurtkulağı Özge, Küçük Celalettin, Mamiş Mehmet Selim, Metin Hatice, Nas Necip, Ocak Serin Sibel, Olmuşçelik Oktay, Oral Alihan, Özbilen Muhammet, Özdemir Erkan, Özmen Ensar, Öztop Hikmet, Ozturk Huseyin Ali, Özüdoğru Osman, Sağlam Emel, Serin Hatice Özge, Sözel Hasan, Şahin Cem, Şahin Tekin Melisa, Şahiner Enes Seyda, Şanibaş Ahmet Veli, Şahintürk Yasin, Şıvgın Hakan, Tanrıkulu Abdullah, Taslamacıoğlu Duman Tuba, Tazegul Gokhan, Topan Elif Duygu, Tunca Hasan, Uyar Seyit, Ünal Çetin Ece, Yalçın Nazif, Yalçın Kehribar Demet, Yaylacı Selçuk, Yıldırım Mehmet Serdar, Yıldırım Hasan Esat, Yıldız Hüseyin, Yıldız Pınar, Yücel Hasan Esat, Zengin Oğuzhan, Zeynettin Ali, Atik Fatih, Aslan Selin Müge, Akyıldız Mert, Aslan Nurcan, Babacan Çelikel Sare, Bakan Suat Baran, Durmuş Merve, Karacay Mert, Koçyiğitoğlu Çağatay, Paşa Gökçe, Sivri Selvinaz, Şahin Tutku Naz, Tosun Yağmur Sena, Totik Zeynep Gizem, Ulutaş Rabia, Yazıcı Tuğçe Nur, Yılmaz Emrah, Yıldız Hamit, Sönmez Alper, Doğru Teoman

Аннотация

Introduction: Metabolic dysfunction-associated steatotic liver disease (MASLD) prevalence data in Türkiye is limited. We aimed to determine the nationwide prevalence of MASLD and advanced hepatic fibrosis risk in subjects with cardiometabolic risk factors (CMRF). Despite recent international consensus redefining fatty liver disease terminology, no nationwide MASLD study has been reported in Türkiye. Methods: This cross-sectional study included 14,371 adults with ≥1 CMRF from 44 centers across 31 cities. MASLD was diagnosed using liver ultrasonography plus cardiometabolic criteria. Advanced fibrosis risk was assessed by fibrosis-4 (FIB-4) score (≥1.3 for ≤65 years; ≥2.0 for >65 years). Logistic regression was used to identify independent predictors of high FIB-4. Results: A total of 61.4% of participants were women, the mean age was 51.3 ± 14.4 years, and the mean BMI was 31.4 ± 6.0 kg/m2. MASLD prevalence was 75.7% (n = 10,873), rising with the number of CMRFs (56.5% with one factor vs. 83.4% with all). The prevalence of high FIB-4 scores was 12.0% overall, being lower in MASLD patients than non-MASLD patients (11.2% vs. 14.4%, p < 0.001). FIB-4 scores decreased with increasing BMI (28.1% underweight vs. 8.7% class III obesity). Male sex, T2DM, and hypertension independently predicted high FIB-4 scores, while smoking, higher BMI, and MASLD were inversely associated. Conclusions: Three-quarters of Turkish adults with CMRF have MASLD. Standard FIB-4 thresholds may underestimate fibrosis risk in obese and smoking populations, underscoring the need for adjusted cut-offs or alternative tools. This study is the first to provide nationwide MASLD prevalence data in Türkiye.

Prevalence of MASLD and Fibrosis Risk in Turkish Adults with Cardiometabolic Risk Factors: A Nationwide Multicenter Study (DAHUDER MASLD Study).

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