Seizure · 2025
The structure-function dissociation in mesial temporal lobe epilepsy with temporopolar blurring.
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Li Yuming, Liu Peiwen, Lin Qiuxing, Li Wei, Zhang Yingying, Li Xiuli, Cao Danyang, Huang Xiang, Huang Kailing, Gong Qiyong, Zhou Dong, An Dongmei
Аннотация
OBJECTIVES: While ipsilateral temporopolar blurring (TPB) has been associated with white matter degeneration in temporal lobe epilepsy with hippocampal sclerosis (TLE-HS), its influence within the large-scale neural networks remains unclear. This study investigates the network-level topological alterations associated with TPB through multilayer network analysis.
METHODS: This retrospective study investigated the impact of TPB on topological architecture of structural (SCN) and functional connectivity networks (FCN) in patients with TLE-HS using graph theory analysis. We further calculated the weighted multiplex participation coefficient (wMxP) to quantify the SCN-FCN interaction in a multiplex connectome.
RESULTS: In total, 105 patients with TLE-HS (60 TPB+; 45 TPB-) and 61 healthy controls were enrolled. We found similar global network organization but altered nodal topological properties between TPB+ and TPB- in single-layer analysis, predominantly across the default mode network, visual network, and subcortical ROIs. Additionally, TPB+ showed decreased average wMxP (t(df=97) = -2.265, p < 2.2e-16) and lower nodal wMxP in default mode network and ipsilateral thalamus (t(df=97)=-2.404, pfwer=0.0408) than those in TPB-.
CONCLUSIONS: We demonstrate that disrupted topological architecture associated with TPB in TLE-HS were primarily and locally distributed in brain regions with rich connections to the temporal pole. The dissociation between SN and FN may indicate compensatory functional adjustments in TLE.
METHODS: This retrospective study investigated the impact of TPB on topological architecture of structural (SCN) and functional connectivity networks (FCN) in patients with TLE-HS using graph theory analysis. We further calculated the weighted multiplex participation coefficient (wMxP) to quantify the SCN-FCN interaction in a multiplex connectome.
RESULTS: In total, 105 patients with TLE-HS (60 TPB+; 45 TPB-) and 61 healthy controls were enrolled. We found similar global network organization but altered nodal topological properties between TPB+ and TPB- in single-layer analysis, predominantly across the default mode network, visual network, and subcortical ROIs. Additionally, TPB+ showed decreased average wMxP (t(df=97) = -2.265, p < 2.2e-16) and lower nodal wMxP in default mode network and ipsilateral thalamus (t(df=97)=-2.404, pfwer=0.0408) than those in TPB-.
CONCLUSIONS: We demonstrate that disrupted topological architecture associated with TPB in TLE-HS were primarily and locally distributed in brain regions with rich connections to the temporal pole. The dissociation between SN and FN may indicate compensatory functional adjustments in TLE.