Clinical nutrition (Edinburgh, Scotland) · 2026
Effects of an early, late, and self-selected time-restricted eating intervention on weight loss maintenance in adults with overweight or obesity: A 12-month follow-up of a randomized controlled trial.
СтатьяРандомизированное исследованиеНазвание и аннотация: Перевод пока не подготовлен
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Camacho-Cardenosa Alba, Merchán-Ramírez Elisa, Clavero-Jimeno Antonio, De-la-O Alejandro, Romero-Noguera José María, Martín-Rodríguez José L, Muñoz-Torres Manuel, Labayen Idoia, Ruiz Jonatan R, Dote-Montero Manuel
Аннотация
BACKGROUND & AIMS: Time-restricted eating (TRE), regardless of the eating window timing, promotes modest weight loss and improves cardiometabolic health. However, the sustained maintenance of these benefits over the long term is unclear. This study aims to investigate the effects of TRE schedules-8-h windows in the early day, late day, and participant-selected times-on body weight loss maintenance compared to usual care (UC), 12 months after a 12-week intervention in adults with overweight or obesity.
METHODS: This parallel-group, randomized controlled trial recruited 99 adults with overweight or obesity (50% women; age: 49.0 ± 6.5 years; body mass index: 32.0 ± 3.8 kg/m2). Participants were randomly assigned to: i) usual care (UC; n = 25), that maintained their habitual ≥12-h eating window, ii) early TRE (n = 25), 8-h eating window starting before 10:00, iii) late TRE (n = 27), 8-h eating window starting after 13:00, and iv) self-selected TRE (n = 22), participant chosen 8-h eating window. All groups received a Mediterranean diet education program. Body weight, fat mass, and fat-free mass were assessed at baseline, 6 weeks, 12 weeks (i.e., end of intervention), and 12 months post-intervention, using a multi-frequency segmental bioelectrical impedance analyzer.
RESULTS: 99 participants were randomized into UC (n = 25), early (n = 25), late (n = 27), and self-selected (n = 22). At the 12-month follow-up assessment, early (p = 0.01) and late TRE (p = 0.02) maintained significantly greater body weight loss compared with UC. Fat mass loss remained significantly lower in early TRE compared with UC (p = 0.04). The reduction of fat-free mass persisted in both early TRE (p = 0.051; tendency) and late TRE (p = 0.04) compared with UC. These differences with the UC were further reinforced after pooling the three TRE schedules. During the 12-month follow-up period, 26% of participants reported having engaged in TRE.
CONCLUSION: A 12-week TRE intervention may represent an effective long-term strategy for maintaining body weight loss up to 12 months in adults with overweight or obesity.
TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT05310721.
METHODS: This parallel-group, randomized controlled trial recruited 99 adults with overweight or obesity (50% women; age: 49.0 ± 6.5 years; body mass index: 32.0 ± 3.8 kg/m2). Participants were randomly assigned to: i) usual care (UC; n = 25), that maintained their habitual ≥12-h eating window, ii) early TRE (n = 25), 8-h eating window starting before 10:00, iii) late TRE (n = 27), 8-h eating window starting after 13:00, and iv) self-selected TRE (n = 22), participant chosen 8-h eating window. All groups received a Mediterranean diet education program. Body weight, fat mass, and fat-free mass were assessed at baseline, 6 weeks, 12 weeks (i.e., end of intervention), and 12 months post-intervention, using a multi-frequency segmental bioelectrical impedance analyzer.
RESULTS: 99 participants were randomized into UC (n = 25), early (n = 25), late (n = 27), and self-selected (n = 22). At the 12-month follow-up assessment, early (p = 0.01) and late TRE (p = 0.02) maintained significantly greater body weight loss compared with UC. Fat mass loss remained significantly lower in early TRE compared with UC (p = 0.04). The reduction of fat-free mass persisted in both early TRE (p = 0.051; tendency) and late TRE (p = 0.04) compared with UC. These differences with the UC were further reinforced after pooling the three TRE schedules. During the 12-month follow-up period, 26% of participants reported having engaged in TRE.
CONCLUSION: A 12-week TRE intervention may represent an effective long-term strategy for maintaining body weight loss up to 12 months in adults with overweight or obesity.
TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT05310721.