European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2025
Within patient horizontal gene transfer dynamics of a blaNDM-7 plasmid among four different bacterial species.
СтатьяКлинический случайНазвание и аннотация: Перевод пока не подготовлен
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van Katwijk O, Mulder M, van Alphen L, Landman F, Hendrickx A, Verkerk A, Sligman L, Schnabel R, van der Zwet W, Smeets E, Dirks Jamc, Jamin C
Аннотация
PURPOSE: We describe the case of a 73-year old male who was found to be a carrier of an blaNDM -producing Citrobacter freundii shortly after admission. During his admission, he developed abdominal abscesses and received multiple courses of piperacillin-tazobactam. In the following months, he was found to carry three other carbapenemase-positive species: Klebsiella oxytoca, Raoultella planticola and Serratia marscescens. RESULTS: Two of these strains had clustering carbapenem-sensitive isolates cultured before. The species all carried an blaNDM-7 encoding incX3 plasmid, which demonstrated horizontal gene transfer within this patient.
CONCLUSION: This case report underlines the importance of mobile genetic elements in infection control, as they serve as transmission vehicles for antimicrobial resistance beyond the spread of identical bacterial strains.
CONCLUSION: This case report underlines the importance of mobile genetic elements in infection control, as they serve as transmission vehicles for antimicrobial resistance beyond the spread of identical bacterial strains.