Infectious diseases (London, England) · 2025
Carbapenemase production and in-hospital mortality associated with multidrug-resistant bacteria: a retrospective study conducted in Granada, Spain.
СтатьяНаблюдательное исследованиеНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Redruello-Guerrero Pablo, Fernández-Martínez Nicolás Francisco, García-Marín Cristina, Martín-delosReyes Luis Miguel, Lorusso Nicola, Millán-Cachinero Carlos, Valero-Ubierna María Del Carmen, Rivera-Izquierdo Mario
Аннотация
BACKGROUND: Multidrug-resistant bacteria (MDR) represent a significant global health concern and vary in specific settings. Spain reported several annual deaths attributed to MDR bacteria, mainly carbapenemase-producing Enterobacterales.
OBJECTIVES: We aimed to characterise the incidence and temporal trends of MDR bacterial infections or colonisations reported within the province of Granada (data from five hospitals), and to investigate factors linked to clinical vulnerability.
METHODS: We conducted an observational retrospective study (2014-2022) using the Andalusian Epidemiological Surveillance System. We employed descriptive, bivariate analyses and geographical mapping. Multivariable logistic regression models were adjusted to identify factors associated with (1) carbapenemase-production and (2) in-hospital mortality.
RESULTS: We included 1482 patients. The main microorganisms identified were Klebsiella spp., Escherichia spp. and Acinetobacter baumannii. Carbapenemases were detected in 23% of cases, and were associated with higher in-hospital mortality rates (OR: 1.92; 95% confidence interval (95% CI): 1.31-2.81) and male sex (OR: 1.50; 95% CI: 1.01-2.23). The overall in-hospital mortality rate was estimated at 18.1%. Infections caused by A. baumannii (OR: 2.11; 95% CI: 1.41-3.13) or carbapenemase-producing Klebsiella pneumoniae (OR: 2.11; 95% CI: 1.28-3.45) were associated with increased mortality.
CONCLUSIONS: These findings contribute to our understanding of the characteristics associated with carbapenemase-producing and early mortality resulting from MDR bacteria. This study offers insights into the factors associated with clinical vulnerability, which may improve future preventive measures.
OBJECTIVES: We aimed to characterise the incidence and temporal trends of MDR bacterial infections or colonisations reported within the province of Granada (data from five hospitals), and to investigate factors linked to clinical vulnerability.
METHODS: We conducted an observational retrospective study (2014-2022) using the Andalusian Epidemiological Surveillance System. We employed descriptive, bivariate analyses and geographical mapping. Multivariable logistic regression models were adjusted to identify factors associated with (1) carbapenemase-production and (2) in-hospital mortality.
RESULTS: We included 1482 patients. The main microorganisms identified were Klebsiella spp., Escherichia spp. and Acinetobacter baumannii. Carbapenemases were detected in 23% of cases, and were associated with higher in-hospital mortality rates (OR: 1.92; 95% confidence interval (95% CI): 1.31-2.81) and male sex (OR: 1.50; 95% CI: 1.01-2.23). The overall in-hospital mortality rate was estimated at 18.1%. Infections caused by A. baumannii (OR: 2.11; 95% CI: 1.41-3.13) or carbapenemase-producing Klebsiella pneumoniae (OR: 2.11; 95% CI: 1.28-3.45) were associated with increased mortality.
CONCLUSIONS: These findings contribute to our understanding of the characteristics associated with carbapenemase-producing and early mortality resulting from MDR bacteria. This study offers insights into the factors associated with clinical vulnerability, which may improve future preventive measures.