Alzheimer's & dementia : the journal of the Alzheimer's Association · 2013
Focal hemosiderin deposits and β-amyloid load in the ADNI cohort.
СтатьяМногоцентровое исследованиеПоддержка NIH: внешняя программаПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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Kantarci Kejal, Gunter Jeffrey L, Tosakulwong Nirubol, Weigand Stephen D, Senjem Matthew S, Petersen Ronald C, Aisen Paul S, Jagust William J, Weiner Michael W, Jack Clifford R, Alzheimer's Disease Neuroimaging Initiative
Аннотация
BACKGROUND: Prevalence and risk factors for focal hemosiderin deposits are important considerations when planning amyloid-modifying trials for treatment and prevention of Alzheimer's disease (AD).
METHODS: Subjects were cognitively normal (n = 171), early-mild cognitive impairment (MCI) (n = 240), late-MCI (n = 111), and AD (n = 40) from the Alzheimer's Disease Neuroimaging Initiative (ADNI). Microhemorrhages and superficial siderosis were assessed at baseline and on all available MRIs at 3, 6, and 12 months. β-amyloid load was assessed with (18)F-florbetapir positron emission tomography.
RESULTS: Prevalence of superficial siderosis was 1% and prevalence of microhemorrhages was 25% increasing with age (P < .001) and β-amyloid load (P < .001). Topographic densities of microhemorrhages were highest in the occipital lobes and lowest in the deep/infratentorial regions. A greater number of microhemorrhages at baseline was associated with a greater annualized rate of additional microhemorrhages by last follow-up (rank correlation = 0.49; P < .001).
CONCLUSIONS: Focal hemosiderin deposits are relatively common in the ADNI cohort and are associated with β-amyloid load.
METHODS: Subjects were cognitively normal (n = 171), early-mild cognitive impairment (MCI) (n = 240), late-MCI (n = 111), and AD (n = 40) from the Alzheimer's Disease Neuroimaging Initiative (ADNI). Microhemorrhages and superficial siderosis were assessed at baseline and on all available MRIs at 3, 6, and 12 months. β-amyloid load was assessed with (18)F-florbetapir positron emission tomography.
RESULTS: Prevalence of superficial siderosis was 1% and prevalence of microhemorrhages was 25% increasing with age (P < .001) and β-amyloid load (P < .001). Topographic densities of microhemorrhages were highest in the occipital lobes and lowest in the deep/infratentorial regions. A greater number of microhemorrhages at baseline was associated with a greater annualized rate of additional microhemorrhages by last follow-up (rank correlation = 0.49; P < .001).
CONCLUSIONS: Focal hemosiderin deposits are relatively common in the ADNI cohort and are associated with β-amyloid load.
Предметные рубрики MeSH
AgedAged, 80 and overAlzheimer DiseaseAmyloid beta-PeptidesAnalysis of VarianceAniline CompoundsApolipoprotein E4Cognition DisordersCohort StudiesDisease ProgressionEthylene GlycolsFemaleHemosiderosisHumansIntracranial HemorrhagesMagnetic Resonance ImagingMalePositron-Emission TomographyTime Factors