[Microelementosis with iron metabolism disorder: the nomenclature and classification].

In the discussion article the basic rules of human microelementosis theory (A. P. Avtsyn et al., 1991) and the review of modern data devoted to molecular-genetic mechanisms of iron homeostasis are represented. The conception of iron microelementosis (siderosis) with appropriate nomenclature and classification has been formulated. The main types of siderosis have been singled out as well hyposiderosis (a deficiency of iron), hypersiderosis (redundant accumulation of iron) and dissiderosis (an imbalance, redistribution of iron between functional and storage pools). In addition each type of siderosis includes primary and secondary variants. The primary variants of siderosis embrace diseases associated with mutations with iron-related genes. The secondary siderosis includes pathological processes associated with various diseases and complicated theirs courses.