bioRxiv : the preprint server for biology · 2026
A precise atlas of the human subcortex.
СтатьяПрепринтНазвание и аннотация: Перевод пока не подготовлен
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Friedrich Helen, Sahin Ilkem Aysu, Rajamani Nanditha, Alho Eduardo J L, Holanda Vanessa Milanese, Oxenford Simon, Brammerloh Malte, Goede Lukas L, Matthies Cordula, Volkmann Jens, Meyer Garance M, Kirilina Evgeniya, Pijar Julianna, Horisawa Shiro, Howard Calvin, Garimella Arun, Li Ningfei, Fox Michael D, Friedrich Maximilian U, Horn Anja K E, Edlow Brian L, Neudorfer Clemens, Horn Andreas
Аннотация
Clinical interventions and neuroimaging in the subcortex require anatomical definitions that exceed the resolution and anatomical detail of currently available deformable brain atlases. Here, we introduce a high-resolution human brain atlas comprising 95 manually segmented grey and white matter structures as well as 82 white matter tracts compiled from a multitude of resources including ex-vivo MRI, histology, fibre dissections, and neuroanatomy textbooks. The atlas is defined at an isotropic resolution of 100 μm and can be precisely deformed to individual subject brain anatomy. By providing precise definitions of both grey and white matter structures within and around the basal ganglia, thalamus, subthalamus, midbrain and cerebellum, the atlas provides a foundational resource for stereotactic surgery and subcortical brain imaging research, as well as for development of next-generation neuromodulation strategies.