Emerging Role of Corynebacterium in Breast Abscesses: Clinical Profiles, Resistance Patterns, and Recommendations.

Background Corynebacterium species are emerging pathogens in breast abscesses, with unique clinical, pathological, and antibiotic resistance patterns that pose diagnostic and therapeutic challenges. This study aimed to evaluate the clinical, pathological, and microbiological characteristics of Corynebacterium-associated breast abscesses, with a focus on antibiotic resistance and evidence-based management. Methodology This retrospective observational study over eight years analyzed 42 patients with Corynebacterium-positive breast abscesses. Results Most patients were ≤35 years old (22, 52.4%), and non-lactating (39, 92.9%). Periductal inflammation was found in 39 (92.3%) patients. Ciprofloxacin and clindamycin resistance was high (39, 92.9%), while vancomycin and linezolid showed 100% sensitivity. The most common species isolated was Corynebacterium striatum (n = 9) isolated from the 18 strains of Corynebacterium species that were subtyped. Conclusions This study underscores non-lactational predominance and high antibiotic resistance in Corynebacterium-associated abscesses, advocating targeted therapy based on susceptibility testing.