Disease stage-specific atrophy markers in Alzheimer's disease.
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Baumeister Hannah, Gellersen Helena M, Polk Sarah E, Lattmann René, Wuestefeld Anika, Wisse Laura E M, Glenn Trevor, Yakupov Renat, Stark Melina, Kleineidam Luca, Roeske Sandra, Morgado Barbara Marcos, Esselmann Hermann, Brosseron Frederic, Ramirez Alfredo, Lüsebrink Falk, Synofzik Matthis, Schott Björn H, Schmid Matthias C, Hetzer Stefan, Dechent Peter, Scheffler Klaus, Ewers Michael, Hellmann-Regen Julian, Ersözlü Ersin, Spruth Eike, Gemenetzi Maria, Fliessbach Klaus, Bartels Claudia, Rostamzadeh Ayda, Glanz Wenzel, Incesoy Enise I, Janowitz Daniel, Rauchmann Boris-Stephan, Kilimann Ingo, Sodenkamp Sebastian, Coenjaerts Marie, Spottke Annika, Peters Oliver, Priller Josef, Schneider Anja, Wiltfang Jens, Buerger Katharina, Perneczky Robert, Teipel Stefan, Laske Christoph, Wagner Michael, Ziegler Gabriel, Jessen Frank, Düzel Emrah, Berron David, DELCODE study group
Аннотация
METHODS: We included 363 older adults; healthy controls (HC) who were negative or positive for amyloidbeta (Aβ) and Aβ-positive patients with subjective cognitive decline (SCD), mild cognitive impairment, or dementia of the Alzheimer type. MRI and neuropsychological assessments were administered annually for up to three years.
RESULTS: Accelerated atrophy of distinct MTL subregions was evident already during preclinical AD. Symptomatic disease stages most notably differed in their hippocampal and parietal atrophy signatures. Associations of atrophy markers and cognitive inventories varied by intended use and disease stage.
DISCUSSION: With the appropriate readout, MRI can detect abnormal atrophy already during preclinical AD. To optimize performance, MRI readouts should be tailored to the targeted disease stage and intended use.