[Combined use of metformin and Diane35 in polycystic ovary syndrome].

UNLABELLED: The aim of our study was to compare the effect of Metformin applied independently to the effect of Metformin used in combination with Diane35, the latter given only during the first two months of the treatment.

METHODS

In this prospective, open clinical study, 30 women with PCOS were included, divided in two groups 15 women each. Group 1 received 850 mg Metformin twice a day and group 2 in which Diane35 was added to the same treatment only during the first two months of the investigation. In addition the following tests have been made--immune reactive insulin, total testosterone, SHBG, free androgen index, anthropometric and some biochemical indices.

RESULTS

Much better decreasing of the level of testosterone and free androgen index in group 2, without worsening of the anthropometric and biochemical indices.

CONCLUSION

The combination of Metformin with the intermittent application of Diane35 is an appropriate alternative for the pathogenic influence and clinical improvement of the symptoms of androgen excess in cases with PCOS.