[Research progress of biomarkers in nasal secretions in endotypes diagnosis and clinical application of chronic rhinosinusitis].

With the development of studies on the endotypes of chronic rhinosinusitis （CRS） and the biomarkers of nasal secretions, the studies of CRS endotypes based on nasal secretion have become more abundant. This paper summarizes the endotypes classification of CRS, the collection methods of nasal secretion and the nasal secretion biomarkers related to the endotypes of CRS, in order to provide a reference for establishing the corresponding endotypes of CRS based on the nasal secretion biomarkers.