Journal of integrative medicine · 2026
Enhancing pregnancy outcomes in recurrent implantation failure: The role of acupuncture in improving endometrial receptivity.
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Li Hong-Zhu, Wu Ying-Jie, Li Xue-Rong, Deng Bing, Pang Yu-Xi, Lin Shi-Yu, Lu Li-Ming, Li Yue-Mei
Аннотация
OBJECTIVE: This study evaluated the effectiveness of acupuncture for improving pregnancy outcomes, endometrial receptivity (ER), and embryo transfer success in patients with recurrent implantation failure (RIF).
METHODS: A retrospective cohort study was conducted using the medical records of 609 RIF patients undergoing frozen embryo transfer between January 2019 and June 2022. Patients were divided into two groups: those receiving acupuncture combined with hormone replacement therapy (HRT) or delayed HRT (d-HRT) and those receiving only HRT/d-HRT. Propensity score matching (PSM) ensured comparability between the groups. Clinical outcomes, including live birth rate (LBR), clinical pregnancy rate (CPR), ongoing pregnancy rate (OPR) and biochemical pregnancy rate (BPR), were analyzed. Endometrial thickness, hormonal levels and uterine blood flow were also assessed.
RESULTS: After PSM, 166 patients were included in each group. The acupuncture group demonstrated significantly higher CPR (36.5%), LBR (28.0%), OPR and BPR compared to the control group (P < 0.05). Endometrial thickness, and estradiol and progesterone levels were also significantly higher, while uterine resistance and pulsatility indices were lower in the acupuncture group (P < 0.05). Predictors of live birth included patient age (< 35 years, hazard ratio [HR] = 0.933, P = 0.002), body mass index (BMI) (< 24 kg/m2, HR = 0.974, P = 0.046), anti-Müllerian hormone (AMH) level (> 2 ng/mL, HR = 1.021, P = 0.043), high-quality embryo transfers (HR = 1.670, P < 0.05), and transferring two embryos (HR = 1.181, P < 0.05).
CONCLUSION: Acupuncture significantly enhanced ER and improved LBR in RIF patients. Younger patients with lower BMI, higher AMH level, and high-quality or dual embryo transfers benefited most from this complementary therapy. Please cite this article as: Li HZ, Wu YJ, Li XR, Deng B, Pang YX, Lin SY, Lu LM, Li YM. Enhancing pregnancy outcomes in recurrent implantation failure: The role of acupuncture in improving endometrial receptivity. J Integr Med. 2026; 24(3):394-402.
METHODS: A retrospective cohort study was conducted using the medical records of 609 RIF patients undergoing frozen embryo transfer between January 2019 and June 2022. Patients were divided into two groups: those receiving acupuncture combined with hormone replacement therapy (HRT) or delayed HRT (d-HRT) and those receiving only HRT/d-HRT. Propensity score matching (PSM) ensured comparability between the groups. Clinical outcomes, including live birth rate (LBR), clinical pregnancy rate (CPR), ongoing pregnancy rate (OPR) and biochemical pregnancy rate (BPR), were analyzed. Endometrial thickness, hormonal levels and uterine blood flow were also assessed.
RESULTS: After PSM, 166 patients were included in each group. The acupuncture group demonstrated significantly higher CPR (36.5%), LBR (28.0%), OPR and BPR compared to the control group (P < 0.05). Endometrial thickness, and estradiol and progesterone levels were also significantly higher, while uterine resistance and pulsatility indices were lower in the acupuncture group (P < 0.05). Predictors of live birth included patient age (< 35 years, hazard ratio [HR] = 0.933, P = 0.002), body mass index (BMI) (< 24 kg/m2, HR = 0.974, P = 0.046), anti-Müllerian hormone (AMH) level (> 2 ng/mL, HR = 1.021, P = 0.043), high-quality embryo transfers (HR = 1.670, P < 0.05), and transferring two embryos (HR = 1.181, P < 0.05).
CONCLUSION: Acupuncture significantly enhanced ER and improved LBR in RIF patients. Younger patients with lower BMI, higher AMH level, and high-quality or dual embryo transfers benefited most from this complementary therapy. Please cite this article as: Li HZ, Wu YJ, Li XR, Deng B, Pang YX, Lin SY, Lu LM, Li YM. Enhancing pregnancy outcomes in recurrent implantation failure: The role of acupuncture in improving endometrial receptivity. J Integr Med. 2026; 24(3):394-402.