Clinical and experimental reproductive medicine · 2026
Average oocyte quality index as a method for scoring dysmorphic oocytes in women with ovarian endometrioma undergoing in vitro fertilization and its correlation with ovarian reserve.
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Park Ju Hee, Kim Seul Ki, Jee Byung Chul
Аннотация
OBJECTIVE: This study investigated whether the average oocyte quality index (AOQI), used as a dysmorphic oocyte scoring system, is higher in women with ovarian endometrioma than in those with unexplained infertility or diminished ovarian reserve (DOR).
METHODS: We included 92 intracytoplasmic sperm injection cycles in which one to five metaphase II oocytes were obtained, and the AOQI was calculated in each cycle. Cycles were grouped according to the indication for in vitro fertilization: current or recurrent endometrioma (34 cycles), unexplained infertility (26 cycles), and DOR (32 cycles). DOR was defined by a serum anti-Müllerian hormone (AMH) level <1.0 ng/mL. The AOQI was compared among the three groups, and the relationship between serum AMH levels and AOQI was also analyzed.
RESULTS: The median AOQI value was significantly higher in the endometrioma group (1.50) compared to the unexplained infertility group (1.00) (p=0.037), but not compared to the DOR group (1.42). Overall, serum AMH level showed an inverse correlation with the AOQI (r=-0.242, p=0.02). Serum AMH level was also inversely correlated with the AOQI in the endometrioma group (r=-0.429, p=0.011), but not in the unexplained infertility and DOR groups. Multiple linear regression analysis demonstrated that serum AMH levels remained inversely correlated with the AOQI (B=-0.176; 95% confidence interval, -0.327 to -0.024; p=0.024), whereas the presence of endometrioma was not a significant factor.
CONCLUSION: The AOQI in the ovarian endometrioma group was higher compared to the unexplained infertility group, and this difference appeared to arise primarily from reduced ovarian reserve rather than the direct impact of endometrioma itself. Serum AMH levels showed an inverse correlation with AOQI, emphasizing the central role of ovarian reserve in determining oocyte quality.
METHODS: We included 92 intracytoplasmic sperm injection cycles in which one to five metaphase II oocytes were obtained, and the AOQI was calculated in each cycle. Cycles were grouped according to the indication for in vitro fertilization: current or recurrent endometrioma (34 cycles), unexplained infertility (26 cycles), and DOR (32 cycles). DOR was defined by a serum anti-Müllerian hormone (AMH) level <1.0 ng/mL. The AOQI was compared among the three groups, and the relationship between serum AMH levels and AOQI was also analyzed.
RESULTS: The median AOQI value was significantly higher in the endometrioma group (1.50) compared to the unexplained infertility group (1.00) (p=0.037), but not compared to the DOR group (1.42). Overall, serum AMH level showed an inverse correlation with the AOQI (r=-0.242, p=0.02). Serum AMH level was also inversely correlated with the AOQI in the endometrioma group (r=-0.429, p=0.011), but not in the unexplained infertility and DOR groups. Multiple linear regression analysis demonstrated that serum AMH levels remained inversely correlated with the AOQI (B=-0.176; 95% confidence interval, -0.327 to -0.024; p=0.024), whereas the presence of endometrioma was not a significant factor.
CONCLUSION: The AOQI in the ovarian endometrioma group was higher compared to the unexplained infertility group, and this difference appeared to arise primarily from reduced ovarian reserve rather than the direct impact of endometrioma itself. Serum AMH levels showed an inverse correlation with AOQI, emphasizing the central role of ovarian reserve in determining oocyte quality.