World journal of gastroenterology · 2025
Sequential changes of antibiotic resistances of Helicobacter pylori in Taiwan from 2019 to 2024.
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Wu Pei-Jui, Tsay Feng-Woei, Wu Deng-Chyang, Yang Jyh-Chin, Chuah Seng-Kee, Chen Kuan-Yang, Chen Chien-Lin, Lee Chia-Long, Shih Chih-An, Liu Yu-Hwa, Shiu Sz-Iuan, Tai Wei-Chen, Kuo Chao-Hung, Lei Wei-Yi, Kao Sung-Shuo, Tsai Tzung-Jiun, Feng I-Che, Koseki Mitsuhiro, Hsu Ping-I, Sheu Ming-Jen
Аннотация
BACKGROUND: Antibiotic resistance significantly impacts the treatment failure rates of Helicobacter pylori (H. pylori) infections.
AIM: To investigate the trends in primary antibiotic resistance of H. pylori in Taiwan over the past six years.
METHODS: We conducted a retrospective analysis of H. pylori isolates from Taiwanese who had not undergone previous treatments (n = 1408), collected between January 1, 2019 and December 31, 2024. Susceptibility of these strains to amoxicillin, clarithromycin, levofloxacin, metronidazole, and tetracycline was tested using the Epsilometer test. We analyzed the trends in single and dual resistance profiles over the study period, and compared antibiotic resistance across different regions (northern, southern and eastern areas) of Taiwan.
RESULTS: The overall resistance rates for H. pylori to amoxicillin, clarithromycin, metronidazole, tetracycline, and levofloxacin in Taiwan were 1.3%, 18.0%, 31.0%, 0.8%, and 28.7%, respectively. Tetracycline resistance increased significantly from 0% in 2019 to 3.5% in 2024 (P value in χ 2 test for linear trend: < 0.001), while metronidazole resistance declined from 35.5% to 13.0% (P value in χ 2 test for linear trend: < 0.001). No significant changes of amoxicillin, clarithromycin and levofloxacin resistances were observed. The dual resistances to clarithromycin plus tetracycline, and metronidazole plus tetracycline both increased significantly from 0% to 1.7% from 2019 to 2024 (P value in χ 2 test for linear trend: < 0.05). Furthermore, no significant regional differences in resistance frequencies except for levofloxacin were detected.
CONCLUSION: Primary antibiotic resistance to tetracycline in H. pylori has increased in Taiwan from 2019 to 2024, while resistance to metronidazole has decreased during the same period. The dual resistance to clarithromycin plus tetracycline and metronidazole plus tetracycline both increased significantly.
AIM: To investigate the trends in primary antibiotic resistance of H. pylori in Taiwan over the past six years.
METHODS: We conducted a retrospective analysis of H. pylori isolates from Taiwanese who had not undergone previous treatments (n = 1408), collected between January 1, 2019 and December 31, 2024. Susceptibility of these strains to amoxicillin, clarithromycin, levofloxacin, metronidazole, and tetracycline was tested using the Epsilometer test. We analyzed the trends in single and dual resistance profiles over the study period, and compared antibiotic resistance across different regions (northern, southern and eastern areas) of Taiwan.
RESULTS: The overall resistance rates for H. pylori to amoxicillin, clarithromycin, metronidazole, tetracycline, and levofloxacin in Taiwan were 1.3%, 18.0%, 31.0%, 0.8%, and 28.7%, respectively. Tetracycline resistance increased significantly from 0% in 2019 to 3.5% in 2024 (P value in χ 2 test for linear trend: < 0.001), while metronidazole resistance declined from 35.5% to 13.0% (P value in χ 2 test for linear trend: < 0.001). No significant changes of amoxicillin, clarithromycin and levofloxacin resistances were observed. The dual resistances to clarithromycin plus tetracycline, and metronidazole plus tetracycline both increased significantly from 0% to 1.7% from 2019 to 2024 (P value in χ 2 test for linear trend: < 0.05). Furthermore, no significant regional differences in resistance frequencies except for levofloxacin were detected.
CONCLUSION: Primary antibiotic resistance to tetracycline in H. pylori has increased in Taiwan from 2019 to 2024, while resistance to metronidazole has decreased during the same period. The dual resistance to clarithromycin plus tetracycline and metronidazole plus tetracycline both increased significantly.