International journal of medical sciences · 2019
Superinfection of hepatitis A virus in hepatocytes infected with hepatitis B virus.
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Win Nan Nwe, Kanda Tatsuo, Ogawa Masahiro, Nakamoto Shingo, Haga Yuki, Sasaki Reina, Nakamura Masato, Wu Shuang, Matsumoto Naoki, Matsuoka Shunichi, Kato Naoya, Shirasawa Hiroshi, Yokosuka Osamu, Okamoto Hiroaki, Moriyama Mitsuhiko
Аннотация
Hepatitis A virus (HAV) infection is a major cause of acute hepatitis including acute liver failure. Hepatitis B infection (HBV) occurs worldwide, with the highest rates in Asian and African countries, and there are several reports that HAV infection may have a more severe clinical course in patients with chronic HBV infection. We previously demonstrated that Japanese miso extracts have inhibitory effects on HAV replication. In the present study, we examined the replication of HAV and HBV in a hepatocyte superinfection model and the inhibitory effects of Japanese miso extracts on both viruses. According to the results, HAV infection inhibited HBV replication in superinfected hepatocytes, and Japanese rice-koji miso extracts had inhibitory effects on HAV replication. Our findings provide useful information for clinicians in managing HAV infection in patients with chronic HBV infection.