Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
Racial, ethnic and sex-specific mechanisms of obstructive sleep apnea and Alzheimer's disease risk.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Murali Komal Patel, Gills Joshua, Turner Arlener, Briggs Anthony, Bernard Mark, Valkanova Elena, Mbah Alfred K, Umasabor-Bubu Ogie Queen, Brewster Glenna, Osakwe Zainab, Williams Natasha, Muller Clemma, Johnson Dayna A, Udeh-Momoh Chinedu T, Ogedegbe Olugbenga, Ayappa Indu, Osorio Ricardo, Jean-Louis Girardin, Ramos Alberto R, Bubu Omonigho Michael
Аннотация
BACKGROUND: Obstructive sleep apnea (OSA) is associated with Alzheimer's disease (AD) risk. Racial-, ethnic-, and sex-specific mechanisms of OSA and AD risk were examined.
METHODS: We analyzed data from 3978 polysomnography patients without cognitive decline aged ≥ 60 including 663 OSA+ patients (284 non-Hispanic White, 207 Black, 172 Hispanic) matched to OSA- cohorts (1:1, n = 663; 1:4, n = 2652) and followed for AD through 2013.
RESULTS: During the 8.5 (standard deviation 1.4) year period, 358 patients developed AD. AD risk was higher for Black (adjusted hazard ratio [aHR] 2.24 [1.24-2.71]), Hispanic (aHR 1.73, [1.38-3.51]), White (aHR 1.83, [1.21-3.37]), male (aHR 2.38, [1.31-3.47]), and female (aHR 1.37, [1.14-2.41]) patients. Hypoxia, sleep fragmentation, and sleep duration (p < 0.01) were associated with increased risk. Black and Hispanic, and female patients showed stronger effects for hypoxia and duration, and fragmentation, respectively.
DISCUSSION: Hypoxia, fragmentation, and duration may underlie racial-, ethnic-, and sex-specific effects of AD risk.
METHODS: We analyzed data from 3978 polysomnography patients without cognitive decline aged ≥ 60 including 663 OSA+ patients (284 non-Hispanic White, 207 Black, 172 Hispanic) matched to OSA- cohorts (1:1, n = 663; 1:4, n = 2652) and followed for AD through 2013.
RESULTS: During the 8.5 (standard deviation 1.4) year period, 358 patients developed AD. AD risk was higher for Black (adjusted hazard ratio [aHR] 2.24 [1.24-2.71]), Hispanic (aHR 1.73, [1.38-3.51]), White (aHR 1.83, [1.21-3.37]), male (aHR 2.38, [1.31-3.47]), and female (aHR 1.37, [1.14-2.41]) patients. Hypoxia, sleep fragmentation, and sleep duration (p < 0.01) were associated with increased risk. Black and Hispanic, and female patients showed stronger effects for hypoxia and duration, and fragmentation, respectively.
DISCUSSION: Hypoxia, fragmentation, and duration may underlie racial-, ethnic-, and sex-specific effects of AD risk.