Challenging diagnosis: unveiling extensive multisystemic sarcoidosis with musculoskeletal involvement through a clinically ambiguous soft tissue mass in the palm.

We report about a 33-year-old man who was referred for assessment of a progressively enlarging mass of the palmar hand muscles, serving as the initial indication of extensive multisystemic sarcoidosis with musculoskeletal involvement. The case underscores the diagnostic challenges associated with the indolent course of sarcoidosis, highlighting the need for recognizing seemingly benign symptoms for early detection. Musculoskeletal imaging findings presented in the case stress the importance of considering sarcoidosis in the differential diagnosis of orthopedic cases. This report emphasizes the importance of understanding possible musculoskeletal imaging findings in sarcoidosis, thereby enabling radiologists to effectively guide patient management.