Vitamin D and Atopic Dermatitis-A Mere Correlation or a Real Supportive Treatment Option?

Atopic dermatitis (AD), a common chronic inflammatory disease in children and adults, is often studied to find the best way to prevent or reduce its severity. One of the substances tested so far is vitamin D. The main aim of this paper was to determine whether vitamin D truly brings benefits to people with AD or whether its action is too insignificant to have clinical significance. The review covered articles-observational studies, several animal studies and randomized controlled trials (RCTs)-available in the PubMed database and published after 2019. Full-text manuscripts in English were used. Observational studies presented both therapeutic effects of vitamin D and its lack of influence on AD. They also determined that vitamin D receptor (VDR) polymorphism may indeed affect the occurrence and severity of this disease. Similarly, the results of vitamin D's effect on AD are inconclusive in RCTs. Meanwhile, animal studies showed only the attenuation of disease symptoms in mice. The still-growing number of studies on vitamin D and its association with AD, due to many internal and external distorting factors, has not been able to provide us with definitive results. It is necessary to conduct further appropriately designed large-scale studies, including long-term observation.