Frontiers in pediatrics · 2025
Lead poisoning in a 10-year-old boy with cyclic vomiting as the first symptom: a case report.
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Ding Liping, Wang Liyuan, Wang Zhiling
Аннотация
INTRODUCTION: Lead is a naturally occurring metal with highly toxic effects on humans, particularly children, who are particularly vulnerable to its long-lasting adverse impacts.
PATIENT CONCERNS: This report presents the case of a 10-year-old boy with a 10-month history of recurrent vomiting. No organic lesions were identified. However, the symptoms were inconsistent with cyclic vomiting syndrome (CVS), given the presence of growth retardation, vitamin D deficiency, bilateral cervical lymphadenopathy, academic difficulties, and impaired concentration.
DIAGNOSIS: Detailed history-taking revealed proximity to a lead mining facility. Blood lead level (BLL) was significantly elevated (382 μg/L), confirming chronic lead poisoning.
INTERVENTIONS: Chelation therapy with dimercaptosuccinic acid (DMSA) was administered for 19 days at a 350 mg/m2 dose per administration.
OUTCOMES: Following treatment, BLL decreased to 168 µg/L, accompanied by significant improvement in vomiting and abdominal pain.
CONCLUSION: Pediatric lead poisoning should be considered in the differential diagnosis of children presenting with cyclic vomiting and neurological symptoms, due to its diagnostic complexity.
PATIENT CONCERNS: This report presents the case of a 10-year-old boy with a 10-month history of recurrent vomiting. No organic lesions were identified. However, the symptoms were inconsistent with cyclic vomiting syndrome (CVS), given the presence of growth retardation, vitamin D deficiency, bilateral cervical lymphadenopathy, academic difficulties, and impaired concentration.
DIAGNOSIS: Detailed history-taking revealed proximity to a lead mining facility. Blood lead level (BLL) was significantly elevated (382 μg/L), confirming chronic lead poisoning.
INTERVENTIONS: Chelation therapy with dimercaptosuccinic acid (DMSA) was administered for 19 days at a 350 mg/m2 dose per administration.
OUTCOMES: Following treatment, BLL decreased to 168 µg/L, accompanied by significant improvement in vomiting and abdominal pain.
CONCLUSION: Pediatric lead poisoning should be considered in the differential diagnosis of children presenting with cyclic vomiting and neurological symptoms, due to its diagnostic complexity.