Frontiers in endocrinology · 2025
Correlation between serum 25-hydroxyvitamin D levels and peripheral neuropathy in type 2 diabetes mellitus.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Chen Senzhen, Chen Jinfeng, Zheng Shujing, Yan Yiling, Huang Mengting, Chen Nuoqi
Аннотация
OBJECTIVE: To investigate the correlation between serum 25-hydroxyvitamin D (25[OH]D) levels and diabetic peripheral neuropathy (DPN) in type 2 diabetes mellitus (T2DM) and to evaluate its predictive value for DPN.
METHODS: Participants were divided into three groups based on 25(OH)D levels: deficient, insufficient, and normal. The relationship between 25(OH)D and DPN, as well as the correlation of 25(OH)D and DPN with various indicators, was analyzed.
RESULTS: Compared to the non-DPN group (NDPN), the DPN group had significantly lower levels of 25(OH)D3 (22.10 ± 0.77 vs. 24.45 ± 0.66 ng/mL) and total 25(OH)D (23.12 ± 0.74 vs. 25.68 ± 0.67 ng/mL). In addition, significant differences were observed in body mass index (BMI), resting heart rate (RHR), triglyceride (TG), free triiodothyronine (FT3), and blood urea nitrogen (BUN) between the two groups (p < 0.05). Multivariate analysis identified 25(OH)D3, total 25(OH)D, FT3, BMI, and RHR as risk factors for DPN. The receiver operating characteristic (ROC) curve analysis revealed that the optimal cutoff value for 25(OH)D3 in predicting DPN in T2DM was 18.85 ng/mL [area under the curve (AUC) 0.76, 95% confidence interval (CI): 0.697-8.823], while the optimal cutoff for total 25(OH)D was 19.94 ng/mL (AUC 0.765, 95% CI: 0.703-0.828).
CONCLUSION: Serum 25(OH)D levels can serve as a simple and effective screening tool to predict the occurrence of DPN in patients with T2DM.
METHODS: Participants were divided into three groups based on 25(OH)D levels: deficient, insufficient, and normal. The relationship between 25(OH)D and DPN, as well as the correlation of 25(OH)D and DPN with various indicators, was analyzed.
RESULTS: Compared to the non-DPN group (NDPN), the DPN group had significantly lower levels of 25(OH)D3 (22.10 ± 0.77 vs. 24.45 ± 0.66 ng/mL) and total 25(OH)D (23.12 ± 0.74 vs. 25.68 ± 0.67 ng/mL). In addition, significant differences were observed in body mass index (BMI), resting heart rate (RHR), triglyceride (TG), free triiodothyronine (FT3), and blood urea nitrogen (BUN) between the two groups (p < 0.05). Multivariate analysis identified 25(OH)D3, total 25(OH)D, FT3, BMI, and RHR as risk factors for DPN. The receiver operating characteristic (ROC) curve analysis revealed that the optimal cutoff value for 25(OH)D3 in predicting DPN in T2DM was 18.85 ng/mL [area under the curve (AUC) 0.76, 95% confidence interval (CI): 0.697-8.823], while the optimal cutoff for total 25(OH)D was 19.94 ng/mL (AUC 0.765, 95% CI: 0.703-0.828).
CONCLUSION: Serum 25(OH)D levels can serve as a simple and effective screening tool to predict the occurrence of DPN in patients with T2DM.