Successful Treatment of Intracranial Infection Caused by Chryseobacterium Indologenes Following Aneurysm Clipping.

Chryseobacteriumindologenes ( C. indologenes ) is a rare but emerging pathogen causing central nervous system (CNS) infections. It poses significant treatment challenges due to its antibiotic resistance. This case report describes the successful management of an intracranial infection caused by C. indologenes after aneurysm clipping, using a multidrug regimen. A retrospective analysis of the clinical course was performed, revealing that the patient responded well to intravenous Trimethoprim-Sulfamethoxazole (TMP/SMZ), oral Sulfamethoxazole (SMZ), and minocycline, resulting in complete resolution of the infection. The microbial characteristics of the infection and the subsequent treatment strategy were reviewed. Infections caused by C. indologenes present significant treatment challenges due to antibiotic resistance. A combination of intravenous TMP/SMZ, oral SMZ, and minocycline can be an effective therapeutic approach for managing such infections.