Experimental hypersplenism in mice.

The authors induced experimental hypersplenism in mice with repeated intraperitoneal injections of methylcellulose ("Tylosa", Messrs. Kabl). Detailed haematological tests of the peripheral blood, a cytomorphological examination of bone marrow and spleen from puncture material and histological tests of the bone marrow, spleen, lymph nodes, thymus, liver, kidneys and lung tissue of hypersplenic mice were carried out. Among the haematological results, apart from findings of marked erythrocyto-, leucocyto- and thrombocytopenia, attention is drawn to the finding, not previously described in the literature, of lowered osmotic resistance and elevated phagocytic activity of the leucocytes of hypersplenic mice.