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Science (New York, N.Y.) · 2022

Fly Cell Atlas: A single-nucleus transcriptomic atlas of the adult fruit fly.

СтатьяResearch Support, N.I.H., IntramuralПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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Li Hongjie, Janssens Jasper, De Waegeneer Maxime, Kolluru Sai Saroja, Davie Kristofer, Gardeux Vincent, Saelens Wouter, David Fabrice P A, Brbić Maria, Spanier Katina, Leskovec Jure, McLaughlin Colleen N, Xie Qijing, Jones Robert C, Brueckner Katja, Shim Jiwon, Tattikota Sudhir Gopal, Schnorrer Frank, Rust Katja, Nystul Todd G, Carvalho-Santos Zita, Ribeiro Carlos, Pal Soumitra, Mahadevaraju Sharvani, Przytycka Teresa M, Allen Aaron M, Goodwin Stephen F, Berry Cameron W, Fuller Margaret T, White-Cooper Helen, Matunis Erika L, DiNardo Stephen, Galenza Anthony, O'Brien Lucy Erin, Dow Julian A T, FCA Consortium§, Jasper Heinrich, Oliver Brian, Perrimon Norbert, Deplancke Bart, Quake Stephen R, Luo Liqun, Aerts Stein, Agarwal Devika, Ahmed-Braimah Yasir, Arbeitman Michelle, Ariss Majd M, Augsburger Jordan, Ayush Kumar, Baker Catherine C, Banisch Torsten, Birker Katja, Bodmer Rolf, Bolival Benjamin, Brantley Susanna E, Brill Julie A, Brown Nora C, Buehner Norene A, Cai Xiaoyu Tracy, Cardoso-Figueiredo Rita, Casares Fernando, Chang Amy, Clandinin Thomas R, Crasta Sheela, Desplan Claude, Detweiler Angela M, Dhakan Darshan B, Donà Erika, Engert Stefanie, Floc'hlay Swann, George Nancy, González-Segarra Amanda J, Groves Andrew K, Gumbin Samantha, Guo Yanmeng, Harris Devon E, Heifetz Yael, Holtz Stephen L, Horns Felix, Hudry Bruno, Hung Ruei-Jiun, Jan Yuh Nung, Jaszczak Jacob S, Jefferis Gregory S X E, Karkanias Jim, Karr Timothy L, Katheder Nadja Sandra, Kezos James, Kim Anna A, Kim Seung K, Kockel Lutz, Konstantinides Nikolaos, Kornberg Thomas B, Krause Henry M, Labott Andrew Thomas, Laturney Meghan, Lehmann Ruth, Leinwand Sarah, Li Jiefu, Li Joshua Shing Shun, Li Kai, Li Ke, Li Liying, Li Tun, Litovchenko Maria, Liu Han-Hsuan, Liu Yifang, Lu Tzu-Chiao, Manning Jonathan, Mase Anjeli, Matera-Vatnick Mikaela, Matias Neuza Reis, McDonough-Goldstein Caitlin E, McGeever Aaron, McLachlan Alex D, Moreno-Roman Paola, Neff Norma, Neville Megan, Ngo Sang, Nielsen Tanja, O'Brien Caitlin E, Osumi-Sutherland David, Özel Mehmet Neset, Papatheodorou Irene, Petkovic Maja, Pilgrim Clare, Pisco Angela Oliveira, Reisenman Carolina, Sanders Erin Nicole, Dos Santos Gilberto, Scott Kristin, Sherlekar Aparna, Shiu Philip, Sims David, Sit Rene V, Slaidina Maija, Smith Harold E, Sterne Gabriella, Su Yu-Han, Sutton Daniel, Tamayo Marco, Tan Michelle, Tastekin Ibrahim, Treiber Christoph, Vacek David, Vogler Georg, Waddell Scott, Wang Wanpeng, Wilson Rachel I, Wolfner Mariana F, Wong Yiu-Cheung E, Xie Anthony, Xu Jun, Yamamoto Shinya, Yan Jia, Yao Zepeng, Yoda Kazuki, Zhu Ruijun, Zinzen Robert P

Аннотация

For more than 100 years, the fruit fly Drosophila melanogaster has been one of the most studied model organisms. Here, we present a single-cell atlas of the adult fly, Tabula Drosophilae, that includes 580,000 nuclei from 15 individually dissected sexed tissues as well as the entire head and body, annotated to >250 distinct cell types. We provide an in-depth analysis of cell type-related gene signatures and transcription factor markers, as well as sexual dimorphism, across the whole animal. Analysis of common cell types between tissues, such as blood and muscle cells, reveals rare cell types and tissue-specific subtypes. This atlas provides a valuable resource for the Drosophila community and serves as a reference to study genetic perturbations and disease models at single-cell resolution.

Предметные рубрики MeSH

ИП Урсолов Владлен Сергеевич

ИНН 500118482352 · ОГРНИП 314500117700049

Реквизиты и контакты