[The value of genetic diagnosis of deafness in evaluating the prognosis of cochlear implantation].

Congenital deafness is known as the most common birth defect, and most sufferers from it manifest sensorineural hearing loss （SNHL）, with hereditary factors responsible for approximately 60% of the cases of deafness. At present, cochlear implantation （CI） is regarded as the most mature and effective solution to treating severe and extremely severe SNHL. However, the outcome of implantation varies due to different genetic factors. With whole genome sequencing advancing, more deafness mutant genes and their types have been identified, which is conducive to clarifying the efficacy of CI in the patients with different mutations for clinical practice. This paper is aimed to summarize the different effects of CI on hereditary deafness and the potential mechanism discovered in recent years, and to clarify the role played by the genetic diagnosis of deafness in evaluating the efficacy of cochlear implantation.