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DOI 10.2217/pgs.16.8

Медицинская библиотека · Pharmacogenomics · 2016

A genetic risk score is associated with statin-induced low-density lipoprotein cholesterol lowering.

Leusink Maarten, Maitland-van der Zee Anke H, Ding Bo, Drenos Fotios, van Iperen Erik Pa, Warren Helen R, Caulfield Mark J, Cupples L Adrienne, Cushman Mary, Hingorani Aroon D, Hoogeveen Ron C, Hovingh G Kees, Kumari Meena, Lange Leslie A, Munroe Patricia B, Nyberg Fredrik, Schreiner Pamela J, Sivapalaratnam Suthesh, de Bakker Paul Iw, de Boer Anthonius, Keating Brendan J, Asselbergs Folkert W, Onland-Moret N Charlotte

СтатьяМетаанализПоддержка NIH: внешняя программаResearch Support, N.I.H., IntramuralПоддержка исследования: вне правительства СШАПеревод пока не подготовлен

Аннотация

AIM: To find new genetic loci associated with statin response, and to investigate the association of a genetic risk score (GRS) with this outcome.

PATIENTS &

METHODS

In a discovery meta-analysis (five studies, 1991 individuals), we investigated the effects of approximately 50000 single nucleotide polymorphisms on statin response, following up associations with p < 1 × 10(-4) (three independent studies, 5314 individuals). We further assessed the effect of a GRS based on SNPs in ABCG2, LPA and APOE.

RESULTS

No new SNPs were found associated with statin response. The GRS was associated with reduced statin response: 0.0394 mmol/l per allele (95% CI: 0.0171-0.0617, p = 5.37 × 10(-4)).

CONCLUSION

The GRS was associated with statin response, but the small effect size (˜2% of the average low-density lipoprotein cholesterol reduction) limits applicability.

Для цитирования: Leusink Maarten, Maitland-van der Zee Anke H, Ding Bo, Drenos Fotios, van Iperen Erik Pa, Warren Helen R, Caulfield Mark J, Cupples L Adrienne, Cushman Mary, Hingorani Aroon D, Hoogeveen Ron C, Hovingh G Kees, Kumari Meena, Lange Leslie A, Munroe Patricia B, Nyberg Fredrik, Schreiner Pamela J, Sivapalaratnam Suthesh, de Bakker Paul Iw, de Boer Anthonius, Keating Brendan J, Asselbergs Folkert W, Onland-Moret N Charlotte. A genetic risk score is associated with statin-induced low-density lipoprotein cholesterol lowering.. Pharmacogenomics. 2016. DOI: 10.2217/pgs.16.8.

Предметные рубрики MeSH

ATP Binding Cassette Transporter, Subfamily G, Member 2AdultAgedApolipoproteins ECholesterol, LDLFemaleGenome-Wide Association StudyGenotypeHumansHydroxymethylglutaryl-CoA Reductase InhibitorsMaleMiddle AgedPolymorphism, Single NucleotideRisk Factors
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