HLA-DPA1 gene polymorphism in primary glaucoma.

OBJECTIVE

To explore the association between human leukocyte antigen (HLA)-DPA1 gene polymorphism and primary glaucoma.

PATIENTS AND

METHODS

Six single nucleotide polymorphisms (SNPs) were genotyped in 51 patients and 51 healthy controls through Polymerase Chain Reaction (PCR). The possible association between HLA-DPA1 gene mutation and primary glaucoma was detected using the t-test and the Chi-square test.

RESULTS

Rs1676486 genotype had a significant genetic correlation. Rs3753841 and rs12138977 genotypes had a higher minor-allele frequency in control group. The CT + CC genotype frequency of rs12138977 showed a significant genetic correlation in both case group and control group. Moreover, the rs12138977 polymorphism and corneal thickness had little influence on the occurrence of primary angle-closure glaucoma (PACG). Also, the main risk factors for PACG were intraocular hypertension and short axial length.

CONCLUSIONS

The HLA-DPA1 gene polymorphism may be related to the severity of PACG.