Journal of veterinary internal medicine · 2021
Airway remodeling in horses with mild and moderate asthma.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Bessonnat Amandine, Hélie Pierre, Grimes Carolyn, Lavoie Jean-Pierre
Аннотация
BACKGROUND: There is a remodeling of the central airways in horses with severe asthma but whether a similar process occurs in horses with the mild or moderate asthma (MMA) is unknown.
OBJECTIVES: To evaluate lesions affecting the central airways of horses with MMA.
ANIMALS: Twelve horses with MMA and 8 control horses.
METHODS: Case-control retrospective study of horses classified as MMA affected or controls based on history and bronchoalveolar lavage fluid cytology. Endobronchial biopsies were analyzed using histomorphometry and a semiquantitative histologic scoring system.
RESULTS: Histomorphometry identified epithelial hyperplasia (47 μm2 /μm [34-57 μm2 /μm]; P = .02), a thickened lamina propria (166 μm [73-336 μm]; P = .04), and smooth muscle fibrosis (42% [33%-78%]; P = .04) in horses with MMA when compared to controls horses (24 μm2 /μm [21-80 μm2 /μm]; 76 μm [36-176 μm]; and 33% [26%-52%], respectively). The semiquantitative score results indicated, in horses with MMA, the presence of epithelial hyperplasia (7 of the 12 horses with MMA and only 1 of the 8 control horses had a score of 1/1), and submucosal inflammatory leucocytes in the central airway (11 of the 12 horses with MMA and only 4 of the 8 control horses had a score ≥ 1/2).
CONCLUSIONS AND CLINICAL RELEVANCE: Tissue remodeling of the bronchial lamina propria, epithelium, and smooth muscle was present in horses with MMA.
OBJECTIVES: To evaluate lesions affecting the central airways of horses with MMA.
ANIMALS: Twelve horses with MMA and 8 control horses.
METHODS: Case-control retrospective study of horses classified as MMA affected or controls based on history and bronchoalveolar lavage fluid cytology. Endobronchial biopsies were analyzed using histomorphometry and a semiquantitative histologic scoring system.
RESULTS: Histomorphometry identified epithelial hyperplasia (47 μm2 /μm [34-57 μm2 /μm]; P = .02), a thickened lamina propria (166 μm [73-336 μm]; P = .04), and smooth muscle fibrosis (42% [33%-78%]; P = .04) in horses with MMA when compared to controls horses (24 μm2 /μm [21-80 μm2 /μm]; 76 μm [36-176 μm]; and 33% [26%-52%], respectively). The semiquantitative score results indicated, in horses with MMA, the presence of epithelial hyperplasia (7 of the 12 horses with MMA and only 1 of the 8 control horses had a score of 1/1), and submucosal inflammatory leucocytes in the central airway (11 of the 12 horses with MMA and only 4 of the 8 control horses had a score ≥ 1/2).
CONCLUSIONS AND CLINICAL RELEVANCE: Tissue remodeling of the bronchial lamina propria, epithelium, and smooth muscle was present in horses with MMA.