A numerical study of the effects of ambient temperature and humidity on the particle growth and deposition in the human airway.

A numerical study was conducted on the effects of ambient temperature and humidity on the transportation of sodium chloride particles (100 nm-1 μm) in a human airway model ranging from the nasal cavity to bronchi. A mucus-tissue structure was adopted to model the mass and heat transfer on the airway surface boundary. The temperature and humidity distributions of the respiratory flow were calculated and then the interaction between the particle and water vapor was further analyzed. It was predicted that the particle size grew to the ratio of 5-6 under subsaturation conditions because of hygroscopicity, which shifted the deposition efficiency in opposite directions on dependence of the initial particle size. However, the particles could be drastically raised to 40 times of the initial 100 nm diameter if the supersaturation-induced condensation was established, that was prone to occur under the cold-dry condition, and consequently promoted the deposition significantly. Such behavior might effectively contribute to the revitalized coronavirus disease 2019 (COVID-19) pandemic in addition to the more active virus itself in winter.