Generalized multi task learning framework for glucose forecasting and hypoglycemia detection using simulation to reality.

Continuous prediction of glucose levels and hypoglycemia events is critical for managing type 1 diabetes mellitus (T1DM) under intensive insulin therapy. Existing models focus on a single task, limiting their practicality and adaptability in automated insulin delivery (AID) systems. To address this, a domain-agnostic continual multi-task learning (DA-CMTL) framework that simultaneously performs glucose level forecasting and hypoglycemia event classification within a unified framework is proposed. Trained on simulated datasets via Sim2Real transfer and adapted using elastic weight consolidation, DA-CMTL supports cross-domain generalization. Evaluation on public datasets (DiaTrend, OhioT1DM, and ShanghaiT1DM) yielded a root mean squared error of 14.01 mg/dL, mean absolute error of 10.03 mg/dL, and sensitivity/specificity of 92.13%/94.28% on 30 min prediction. Real-world validation using diabetes-induced rats demonstrated a reduction in time below range from 3.01% to 2.58%, supporting reliable integration as a safety layer in AID systems. These results highlight DA-CMTL's robustness, scalability, and potential to improve safety in AID.