Journal of psychiatry & neuroscience : JPN · 2007
Neurocognitive function in an extended Afrikaner-ancestry family with affective illness.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Savitz Jonathan, van der Merwe Lize, Solms Mark, Ramesar Rajkumar
Аннотация
OBJECTIVE: To characterize the neuropsychological profile of an extended family with unipolar depression (UPD) and other forms of affective illness.
METHOD: We administered a battery of neuropsychological tasks measuring various aspects of executive function and visual and verbal memory to 49 individuals in 1 extended family. Six participants had 1 lifetime episode of major depression (MDE-S), 15 were diagnosed with recurrent major depression (MDE-R), 11 had another DSM-IV diagnosis and 17 subjects were unaffected.
RESULTS: After controlling for multiple confounding factors, including mood and medication, the MDE-R sample made significantly more errors than unaffected relatives on the Stroop Task, a measure of cognitive control.
CONCLUSION: There may be at least 1 subtype of UPD characterized by a state-independent deficit in cognitive control.
METHOD: We administered a battery of neuropsychological tasks measuring various aspects of executive function and visual and verbal memory to 49 individuals in 1 extended family. Six participants had 1 lifetime episode of major depression (MDE-S), 15 were diagnosed with recurrent major depression (MDE-R), 11 had another DSM-IV diagnosis and 17 subjects were unaffected.
RESULTS: After controlling for multiple confounding factors, including mood and medication, the MDE-R sample made significantly more errors than unaffected relatives on the Stroop Task, a measure of cognitive control.
CONCLUSION: There may be at least 1 subtype of UPD characterized by a state-independent deficit in cognitive control.