The American journal of gastroenterology · 1996
Evaluation of short-chain fatty acid enemas: treatment of radiation proctitis.
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al-Sabbagh R, Sinicrope F A, Sellin J H, Shen Y, Roubein L
Аннотация
BACKGROUND: Radiation proctitis is a common complication of abdominal and pelvic radiotherapy; unfortunately, there is no established effective therapy for radiation proctitis. Short-chain fatty acids (SCFA) have been effectively used to treat a variety of colitides. We sought to determine whether SCFA enemas have a role in the treatment of radiation proctitis.
METHODS: Seven patients completed an open-labeled, pilot study to evaluate the effect of SCFA on clinical, endoscopic, and pathological parameters of radiation proctitis.
RESULTS: Four weeks of treatment with SCFA enemas resulted in clinical improvement in all patients. There were modest, but not significant, changes in endoscopic and pathological parameters.
CONCLUSION: SCFA are a promising therapeutic option in radiation proctitis.
METHODS: Seven patients completed an open-labeled, pilot study to evaluate the effect of SCFA on clinical, endoscopic, and pathological parameters of radiation proctitis.
RESULTS: Four weeks of treatment with SCFA enemas resulted in clinical improvement in all patients. There were modest, but not significant, changes in endoscopic and pathological parameters.
CONCLUSION: SCFA are a promising therapeutic option in radiation proctitis.