Respiratory medicine · 2017
Diagnostic performances of the Xpert MTB/RIF in Brazil.
Оценочное исследованиеСтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
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Silva Denise Rossato, Sotgiu Giovanni, D'Ambrosio Lia, Pereira Giovana Rodrigues, Barbosa Márcia Silva, Dias Natan José Dutra, Saderi Laura, Centis Rosella, Migliori Giovanni Battista
Аннотация
BACKGROUND AND OBJECTIVES: As for all tests, the diagnostic performances of Xpert MTB/RIF might be different in settings with different tuberculosis prevalence. Aim of the study is to evaluate the performances of Xpert MTB/RIF to diagnose tuberculosis in Brazil, where 407 culture-confirmed tuberculosis patients were retrospectively enrolled in Rio Grande do Sul, between 2015 and 2016.
METHODS: Sensitivity, specificity, positive and negative predictive values of the test were calculated and a logistic regression analysis was performed to assess the role played by explanatory variables in the occurrence of true positive and negative diagnostic results.
RESULTS: Sensitivity of Xpert MTB/RIF was 100.0%, specificity 92.8%; positive and negative predictive values were 71.4% and 100.0%, respectively. In the HIV- infected sub-group specificity was 59.3%. In the multivariate logistic regression analysis, true positivity was associated with increasing age (1.0; p-value: 0.02) while true positivity and negativity were negatively associated with alcohol abuse.
CONCLUSIONS: Xpert is sensitive and specific in the Brasilian settings.
METHODS: Sensitivity, specificity, positive and negative predictive values of the test were calculated and a logistic regression analysis was performed to assess the role played by explanatory variables in the occurrence of true positive and negative diagnostic results.
RESULTS: Sensitivity of Xpert MTB/RIF was 100.0%, specificity 92.8%; positive and negative predictive values were 71.4% and 100.0%, respectively. In the HIV- infected sub-group specificity was 59.3%. In the multivariate logistic regression analysis, true positivity was associated with increasing age (1.0; p-value: 0.02) while true positivity and negativity were negatively associated with alcohol abuse.
CONCLUSIONS: Xpert is sensitive and specific in the Brasilian settings.
Предметные рубрики MeSH
AdultAntibiotics, AntitubercularBrazilCoinfectionDrug Resistance, BacterialFemaleHIV InfectionsHumansMaleMicrobial Sensitivity TestsMiddle AgedMycobacterium tuberculosisOpportunistic InfectionsPredictive Value of TestsRetrospective StudiesReverse Transcriptase Polymerase Chain ReactionRifampinSensitivity and SpecificityTuberculosis