Journal of arrhythmia · 2026
Percutaneous Left Atrial Appendage Occlusion for Atrial Fibrillation in Cardiac Amyloidosis.
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Almakadma Abdul Hakim, Ibrahim Ramzi, Pham Hoang Nhat, Habib Eiad, Mahmoud Ahmed K, Awad Kamal, Bhakta Mayurkumar D, Yang Eric H, El Masry Hicham Z, Ayoub Chadi, Arsanjani Reza
Аннотация
BACKGROUND: Cardiac amyloidosis (CA) is frequently complicated by atrial fibrillation (AF), yet outcomes after left atrial appendage occlusion (LAAO) in this population remain poorly defined.
METHODS: We conducted a retrospective TriNetX study of adults with AF undergoing LAAO, comparing patients with and without CA after 1:1 propensity matching. Outcomes were assessed using Kaplan-Meier analyses and Cox regression.
RESULTS: Among 532 matched pairs, mortality and major adverse cardiovascular events were similar between groups, whereas major bleeding was higher in CA (HR 1.90).
CONCLUSIONS: LAAO yields comparable ischemic outcomes in CA, though bleeding risk is increased.
METHODS: We conducted a retrospective TriNetX study of adults with AF undergoing LAAO, comparing patients with and without CA after 1:1 propensity matching. Outcomes were assessed using Kaplan-Meier analyses and Cox regression.
RESULTS: Among 532 matched pairs, mortality and major adverse cardiovascular events were similar between groups, whereas major bleeding was higher in CA (HR 1.90).
CONCLUSIONS: LAAO yields comparable ischemic outcomes in CA, though bleeding risk is increased.